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. 2021 Dec 6;53(12):1636–1648. doi: 10.1038/s41588-021-00973-1

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© The Author(s) 2021, corrected publication 2022

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Extended Data Fig. 2 — Enrichment of SNP-based heritability was calculated with LD-score regression. Grey dashed line represents no enrichment (enrichment = 1). Error bars denote standard error of enrichment estimate. Nominal statistically significant enrichment estimates (two-sided P < 0.05) are marked with an asterisk (Conserved_LindbladToh P = 6.5 × 10⁻⁵, SuperEnhancer_Hnisz P = 0.014, TFBS_ENCODE P = 0.017, H3K4me1_peaks_Trynka P = 0.018, Coding_UCSC P = 0.028, H3K9ac_Trynka P = 0.037). The category Conserved_LindbladToh was significant after Bonferroni correction for multiple testing across all categories (N = 28). Due to the regression framework in LDSC, enrichment estimates < 0 are possible (with large standard errors).

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