Table 3. Clinical characteristics according to the follow-up group.
| Characteristics | Follow-up group | Follow-up loss group | P value | |
|---|---|---|---|---|
| No. of patients | 442 (72.1) | 171 (27.9) | ||
| Age, yr | 3.26 ± 4.86 | 4.08 ± 5.90 | 0.082 | |
| Sex | 0.358 | |||
| Male | 270 (61.1) | 97 (56.7) | ||
| Female | 172 (38.9) | 74 (43.3) | ||
| Follow-up discontinuation by | < 0.001 | |||
| Physician | 352 (79.6) | 108 (63.2) | ||
| Patient | 90 (20.4) | 63 (36.8) | ||
| Diagnosis | ||||
| Respiratory infection | 193 (43.7) | 89 (52.0) | 0.279 | |
| Gastrointestinal infection | 69 (15.6) | 42 (24.6) | 0.011 | |
| Urinary tract infection | 75 (17.0) | 15 (8.8) | 0.011 | |
| Other febrile disease | 86 (19.5) | 30 (17.5) | 0.646 | |
| EBV infection | 36 (8.1) | 1 (0.6) | 0.001 | |
| CMV infection | 5 (1.1) | 0 (0) | 0.329 | |
| Physician | < 0.001 | |||
| Non-GI pediatrician | 317 (71.7) | 98 (52.0) | ||
| Pediatric gastroenterologist | 114 (25.8) | 12 (24.6) | ||
| Pediatric resident | 2 (0.5) | 7 (8.8) | ||
| Emergency doctor | 9 (2.0) | 54 (17.5) | ||
| Initial laboratory data | ||||
| AST, IU/L | 199.2 ± 288.6 | 85 ± 59.7 | < 0.001 | |
| ALT, IU/L | 226.4 ± 340.5 | 99.3 ± 71.9 | < 0.001 | |
| TB, mg/dL | 0.60 ± 0.73 | 0.48 ± 0.41 | 0.04 | |
| DB, mg/dL | 0.25 ± 0.46 | 0.17 ± 0.19 | 0.95 | |
| Albumin, g/dL | 4.19 ± 0.48 | 4.30 ± 0.39 | 0.05 | |
| GGT, IU/L | 91.0 ± 133.9 | 51.6 ± 42.6 | 0.32 | |
| ALP, U/L | 349.1 ± 273.1 | 419.0 ± 296.7 | 0.06 | |
| WBC, /uL | 11,871 ± 5,159.7 | 10,992.3 ± 4,737.4 | 0.191 | |
| Peak laboratory data | ||||
| AST, IU/L | 236.3 ± 319.4 | < 0.001* | ||
| ALT, IU/L | 282.1 ± 384.6 | < 0.001* | ||
| TB, mg/dL | 0.63 ± 0.87 | 0.032* | ||
| DB, mg/dL | 0.25 ± 0.49 | 0.1* | ||
| Final laboratory data | ||||
| AST, IU/L | 50.0 ± 32.4 | < 0.001* | ||
| ALT, IU/L | 60.6 ± 68.5 | < 0.001* | ||
| TB, mg/dL | 0.38 ± 0.39 | 0.009* | ||
| DB, mg/dL | 0.12 ± 0.11 | 0.003* | ||
Values are presented as mean ± standard deviation or number (%).
EBV = Epstein-Barr virus, CMV = cytomegalovirus, GI = gastrointestinal, AST = aspartate transaminase, ALT = alanine aminotransferase, TB = total bilirubin, DB = direct bilirubin, GGT = gamma glutamyl transferase, ALP = alkaline phosphatase, WBC = white blood cell count.
*P values were calculated by comparison to initial liver function tests in the follow-up loss group.