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. 2021 Nov 2;36(47):e310. doi: 10.3346/jkms.2021.36.e310

Table 3. Clinical characteristics according to the follow-up group.

Characteristics Follow-up group Follow-up loss group P value
No. of patients 442 (72.1) 171 (27.9)
Age, yr 3.26 ± 4.86 4.08 ± 5.90 0.082
Sex 0.358
Male 270 (61.1) 97 (56.7)
Female 172 (38.9) 74 (43.3)
Follow-up discontinuation by < 0.001
Physician 352 (79.6) 108 (63.2)
Patient 90 (20.4) 63 (36.8)
Diagnosis
Respiratory infection 193 (43.7) 89 (52.0) 0.279
Gastrointestinal infection 69 (15.6) 42 (24.6) 0.011
Urinary tract infection 75 (17.0) 15 (8.8) 0.011
Other febrile disease 86 (19.5) 30 (17.5) 0.646
EBV infection 36 (8.1) 1 (0.6) 0.001
CMV infection 5 (1.1) 0 (0) 0.329
Physician < 0.001
Non-GI pediatrician 317 (71.7) 98 (52.0)
Pediatric gastroenterologist 114 (25.8) 12 (24.6)
Pediatric resident 2 (0.5) 7 (8.8)
Emergency doctor 9 (2.0) 54 (17.5)
Initial laboratory data
AST, IU/L 199.2 ± 288.6 85 ± 59.7 < 0.001
ALT, IU/L 226.4 ± 340.5 99.3 ± 71.9 < 0.001
TB, mg/dL 0.60 ± 0.73 0.48 ± 0.41 0.04
DB, mg/dL 0.25 ± 0.46 0.17 ± 0.19 0.95
Albumin, g/dL 4.19 ± 0.48 4.30 ± 0.39 0.05
GGT, IU/L 91.0 ± 133.9 51.6 ± 42.6 0.32
ALP, U/L 349.1 ± 273.1 419.0 ± 296.7 0.06
WBC, /uL 11,871 ± 5,159.7 10,992.3 ± 4,737.4 0.191
Peak laboratory data
AST, IU/L 236.3 ± 319.4 < 0.001*
ALT, IU/L 282.1 ± 384.6 < 0.001*
TB, mg/dL 0.63 ± 0.87 0.032*
DB, mg/dL 0.25 ± 0.49 0.1*
Final laboratory data
AST, IU/L 50.0 ± 32.4 < 0.001*
ALT, IU/L 60.6 ± 68.5 < 0.001*
TB, mg/dL 0.38 ± 0.39 0.009*
DB, mg/dL 0.12 ± 0.11 0.003*

Values are presented as mean ± standard deviation or number (%).

EBV = Epstein-Barr virus, CMV = cytomegalovirus, GI = gastrointestinal, AST = aspartate transaminase, ALT = alanine aminotransferase, TB = total bilirubin, DB = direct bilirubin, GGT = gamma glutamyl transferase, ALP = alkaline phosphatase, WBC = white blood cell count.

*P values were calculated by comparison to initial liver function tests in the follow-up loss group.