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. 2021 Dec 7;30(1):83–96.e4. doi: 10.1016/j.chom.2021.12.005

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© 2021 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Baseline hCCCoV antibody levels do not correlate with disease severity following SARS-CoV-2 infection

(A) Baseline hCCCoV-normalized ODs are depicted in the heatmap along with demographic information and severity scores. Individuals were given a severity score based on self-reported symptoms: (1) Asymptomatic (n = 8), (2) mild-moderate (n = 69), (3) moderate-severe (n = 26), (4) severe (n = 2), and (5) critical (n = 2).

(B) Comparison of baseline hCCCoV antibody between infected subjects with severity score 3–5 (n = 30) and severity score 1 to 2 (n = 77).

(C) Principal component analysis (PCA) of baseline betacoronavirus IgG-, IgA-, and IgM-normalized ODs. First two components (Dim1 and Dim2) are on the x and y axes, and numbers in parenthesis indicate percent variation explained by each component. The size and color of each bubble represent days and severity of symptoms for 107 SARS-CoV-2-infected subjects. The blue and red shaded areas represent 90% ellipses (Fox and Weisberg, 2019) for severity 3–5 and severity 1 to 2, respectively.