Skip to main content
. 2021 Dec 7;30(1):83–96.e4. doi: 10.1016/j.chom.2021.12.005

Figure 6.

Figure 6

Existing hCCCoV antibody levels associate with the magnitude of the SARS-CoV-2 antibody response after infection, but not vaccination

(A) The normalized OD of antibodies in samples taken 16–40 days after SARS-CoV-2 diagnosis (n = 123) was compared to the five severity scores. Kendall rank correlation coefficients are indicated in the heatmap. P values were corrected by false discovery rate. ∗p < 0.05.

(B–E) Pearson’s formulation was utilized to calculate correlation coefficients, with multiple testing correction with the TestCor package between (B) normalized ODs of baseline hCCCoV antibodies compared to normalized ODs of SARS-CoV-2 antibody in samples collected 16–40 days after infection (n = 41), (C) the percent change from baseline of hCCCoV antibodies compared to SARS-CoV-2 antibody in samples collected between 1 and 15 days after infection (n = 43), (D) baseline hCCCoV-normalized ODs compared to SARS-CoV-2 antibody 20–85 days after vaccination with Pfizer/BioNTech BNT162b2 (n = 256), and (E) the increase in hCCCoV antibodies relative to the baseline sample compared to SARS-CoV-2 antibody in samples collected after vaccination (n = 256).