Table 1.
Strongest tissue-specific associations of novel LOAD genes.
| ADGC & IGAP | ADGC | IGAP | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Genes | Tissue | N | Z | p-value | N | Z | p-value | N | Z | p-value |
| TRIT1 | Brain amygdala | 58,713 | 4.615 | 3.92E-06 | 25,776 | 3.025 | 2.49E-03 | 32,937 | 3.487 | 4.89E-04 |
| TSPAN14 | Cells cultured fibroblasts | 58,624 | 4.572 | 4.83E-06 | 25,687 | 2.224 | 2.61E-02 | 32,937 | 4.136 | 3.54E-05 |
| LRRC8D | Testis | 58,713 | −4.493 | 7.02E-06 | 25,776 | −3.599 | 3.19E-04 | 32,937 | −2.815 | 4.88E-03 |
| SHARPIN | Colon transverse | 58,713 | 4.472 | 7.76E-06 | 25,776 | 3.426 | 6.13E-04 | 32,937 | 2.94 | 3.29E-03 |
| MYCL | Artery coronary | 58,713 | −4.437 | 9.13E-06 | 25,776 | −2.947 | 3.21E-03 | 32,937 | −3.316 | 9.12E-04 |
| CLUAP1 | Cells cultured fibroblasts | 56,140 | 4.333 | 1.47E-05 | 24,133 | 3.948 | 7.89E-05 | 32,007 | 2.31 | 2.09E-02 |
| LTBP2 | Prostate | 58,713 | −4.314 | 1.60E-05 | 25,776 | −2.677 | 7.44E-03 | 32,937 | −3.392 | 6.94E-04 |
| RERE | Heart atrial appendage | 58,713 | −4.249 | 2.15E-05 | 25,776 | −1.44 | 1.50E-01 | 32,937 | −4.399 | 1.09E-05 |
| ARHGEF10L | Artery tibial | 58,684 | −4.198 | 2.69E-05 | 25,747 | −2.698 | 6.97E-03 | 32,937 | −3.218 | 1.29E-03 |
| TMEM14EP | DGN-WB | 58,713 | 4.155 | 3.25E-05 | 25,776 | 3.344 | 8.27E-04 | 32,937 | 2.59 | 9.60E-03 |
| SSBP4 | Esophagus muscularis | 58,713 | −4.142 | 3.44E-05 | 25,776 | −3.937 | 8.24E-05 | 32,937 | −2.048 | 4.06E-02 |
| MTDH | Adipose subcutaneous | 58,449 | 4.094 | 4.24E-05 | 25,512 | 3.338 | 8.42E-04 | 32,937 | 2.515 | 1.19E-02 |
| LRRC25 | Artery tibial | 58,713 | −4.081 | 4.48E-05 | 25,776 | −2.8 | 5.11E-03 | 32,937 | −2.972 | 2.96E-03 |
| TRIB3 | Breast mammary tissue | 58,713 | 4.059 | 4.94E-05 | 25,776 | 3.234 | 1.22E-03 | 32,937 | 2.558 | 1.05E-02 |
| AC007228.9 | Muscle skeletal | 56,813 | −4.056 | 5.00E-05 | 23,876 | −2.445 | 1.45E-02 | 32,937 | −3.245 | 1.17E-03 |
| SCARB1 | Muscle skeletal | 58,713 | 4.041 | 5.33E-05 | 25,776 | 2.576 | 1.00E-02 | 32,937 | 3.116 | 1.83E-03 |
| EXOSC10 | Skin not sun-exposed suprapubic | 58,713 | 4.027 | 5.64E-05 | 25,776 | 1.648 | 9.95E-02 | 32,937 | 3.92 | 8.86E-05 |
| YDJC | Brain putamen basal ganglia | 58,713 | −4.01 | 6.08E-05 | 25,776 | −3.581 | 3.43E-04 | 32,937 | −2.186 | 2.88E-02 |
| VPS13D | Brain cortex | 58,713 | −4.004 | 6.22E-05 | 25,776 | −1.297 | 1.95E-01 | 32,937 | −4.199 | 2.68E-05 |
| ADA | DLPFC | 58,713 | 3.994 | 6.51E-05 | 25,776 | 2.25 | 2.45E-02 | 32,937 | 3.342 | 8.32E-04 |
| AP000553.3 | Nerve tibial | 58,713 | 3.993 | 6.52E-05 | 25,776 | 3.487 | 4.89E-04 | 32,937 | 2.247 | 2.46E-02 |
| CCDC116 | Brain spinal cord cervical c-1 | 58,713 | 3.993 | 6.52E-05 | 25,776 | 3.487 | 4.89E-04 | 32,937 | 2.247 | 2.46E-02 |
| MVB12B | Artery aorta | 58,713 | −3.993 | 6.52E-05 | 25,776 | −2.155 | 3.12E-02 | 32,937 | −3.425 | 6.14E-04 |
| NBAT1 | Artery aorta | 58,713 | −3.973 | 7.09E-05 | 25,776 | −2.623 | 8.71E-03 | 32,937 | −2.984 | 2.84E-03 |
| RABEP1 | Adipose subcutaneous | 58,713 | 3.973 | 7.10E-05 | 25,776 | 2.779 | 5.46E-03 | 32,937 | 2.846 | 4.42E-03 |
| DDX41 | Brain putamen basal ganglia | 52,443 | 3.972 | 7.12E-05 | 23,391 | 3.442 | 5.77E-04 | 29,052 | 2.249 | 2.45E-02 |
| SDS | Brain frontal cortex BA9 | 58,713 | −3.959 | 7.54E-05 | 25,776 | −2.147 | 3.18E-02 | 32,937 | −3.386 | 7.10E-04 |
| UBE2L3 | DGN-WB | 58,713 | −3.956 | 7.61E-05 | 25,776 | −3.584 | 3.38E-04 | 32,937 | −2.112 | 3.47E-02 |
| HARS1 | DGN-WB | 58,713 | −3.955 | 7.64E-05 | 25,776 | −2.201 | 2.77E-02 | 32,937 | −3.334 | 8.57E-04 |
| AREL1 | Brain cerebellar hemisphere | 58,713 | 3.948 | 7.90E-05 | 25,776 | 3.037 | 2.39E-03 | 32,937 | 2.584 | 9.77E-03 |
| MFSD2A | Minor salivary gland | 58,713 | 3.946 | 7.96E-05 | 25,776 | 2.959 | 3.09E-03 | 32,937 | 2.65 | 8.04E-03 |
| FKTN | Brain caudate basal ganglia | 58,713 | 3.944 | 8.02E-05 | 25,776 | 1.11 | 2.67E-01 | 32,937 | 4.284 | 1.84E-05 |
| MT1G | Brain frontal cortex BA9 | 58,713 | 3.941 | 8.13E-05 | 25,776 | 0.741 | 4.58E-01 | 32,937 | 4.605 | 4.12E-06 |
| ARHGEF3 | DLPFC | 58,713 | 3.934 | 8.34E-05 | 25,776 | 3.067 | 2.16E-03 | 32,937 | 2.54 | 1.11E-02 |
| FOLR2 | Minor salivary gland | 58,351 | 3.918 | 8.92E-05 | 25,414 | 4.577 | 4.71E-06 | 32,937 | 1.195 | 2.32E-01 |
| TRAM1 | Esophagus gastroesophageal junction | 58,713 | −3.912 | 9.14E-05 | 25,776 | −3.57 | 3.57E-04 | 32,937 | −2.066 | 3.89E-02 |
| NTRK1 | Artery tibial | 58,713 | 3.886 | 1.02E-04 | 25,776 | 2.197 | 2.80E-02 | 32,937 | 3.245 | 1.17E-03 |
| CLUL1 | Brain caudate basal ganglia | 58,713 | −3.827 | 1.30E-04 | 25,776 | −1.158 | 2.47E-01 | 32,937 | −4.085 | 4.42E-05 |
| ACP1 | Testis | 58,713 | −3.802 | 1.43E-04 | 25,776 | −3.889 | 1.01E-04 | 32,937 | −1.636 | 1.02E-01 |
| L3MBTL2 | Heart atrial appendage | 58,713 | 3.783 | 1.55E-04 | 25,776 | 4.126 | 3.69E-05 | 32,937 | 1.4 | 1.61E-01 |
| CHADL | Heart left ventricle | 58,713 | −3.773 | 1.62E-04 | 25,776 | −4.201 | 2.66E-05 | 32,937 | −1.321 | 1.87E-01 |
| OSER1 | DLPFC | 58,713 | −3.753 | 1.75E-04 | 25,776 | −3.947 | 7.92E-05 | 32,937 | −1.52 | 1.29E-01 |
| EP300 | Lung | 58,713 | 3.715 | 2.03E-04 | 25,776 | 4.318 | 1.58E-05 | 32,937 | 1.141 | 2.54E-01 |
| INPPL1 | Ovary | 58,351 | 3.686 | 2.28E-04 | 25,414 | 4.354 | 1.34E-05 | 32,937 | 1.081 | 2.80E-01 |
| PATJ | Esophagus mucosa | 58,713 | 3.683 | 2.30E-04 | 25,776 | 1.138 | 2.55E-01 | 32,937 | 3.911 | 9.21E-05 |
| RILPL2 | Lung | 57,358 | −3.621 | 2.94E-04 | 24,421 | −0.259 | 7.95E-01 | 32,937 | −4.555 | 5.25E-06 |
| SH3YL1 | Adrenal gland | 58,713 | 3.616 | 2.99E-04 | 25,776 | 3.909 | 9.27E-05 | 32,937 | 1.37 | 1.71E-01 |
| COLCA2 | Stomach | 58,713 | 3.616 | 3.00E-04 | 25,776 | 4.206 | 2.60E-05 | 32,937 | 1.106 | 2.69E-01 |
| ALKAL2 | Brain substantia nigra | 58,713 | 3.583 | 3.40E-04 | 25,776 | 3.898 | 9.69E-05 | 32,937 | 1.335 | 1.82E-01 |
| GDAP1L1 | Artery tibial | 58,713 | 3.575 | 3.51E-04 | 25,776 | 4.141 | 3.46E-05 | 32,937 | 1.11 | 2.67E-01 |
| ECE1 | Heart left ventricle | 58,713 | −3.574 | 3.52E-04 | 25,776 | −0.686 | 4.93E-01 | 32,937 | −4.164 | 3.12E-05 |
| NAV3 | Esophagus gastroesophageal junction | 58,713 | −3.567 | 3.61E-04 | 25,776 | −0.991 | 3.22E-01 | 32,937 | −3.887 | 1.02E-04 |
| NPC2 | Brain hippocampus | 58,713 | −3.467 | 5.26E-04 | 25,776 | −0.133 | 8.94E-01 | 32,937 | −4.511 | 6.44E-06 |
| MAP3K7 | Pancreas | 58,713 | −3.43 | 6.04E-04 | 25,776 | −0.721 | 4.71E-01 | 32,937 | −3.941 | 8.11E-05 |
| RBCK1 | Testis | 58,713 | 3.389 | 7.02E-04 | 25,776 | 0.108 | 9.14E-01 | 32,937 | 4.429 | 9.46E-06 |
| PHB2 | Brain cortex | 58,713 | −3.171 | 1.52E-03 | 25,776 | −0.378 | 7.06E-01 | 32,937 | −3.9 | 9.62E-05 |
| EMG1 | Skin sun-exposed lower leg | 58,713 | 3.138 | 1.70E-03 | 25,776 | 0.183 | 8.55E-01 | 32,937 | 4.029 | 5.61E-05 |
| AC026367.3 | Cells cultured fibroblasts | 58,713 | −3.099 | 1.94E-03 | 25,776 | −4.513 | 6.40E-06 | 32,937 | −0.146 | 8.84E-01 |
| TBC1D1 | Cells cultured fibroblasts | 58,713 | 3.057 | 2.23E-03 | 25,776 | 0.161 | 8.72E-01 | 32,937 | 3.94 | 8.16E-05 |
| RABEPK | Brain substantia nigra | 35,698 | 3.013 | 2.58E-03 | 19,912 | 0.428 | 6.69E-01 | 15,786 | 4.051 | 5.10E-05 |
| AC026367.2 | Brain frontal cortex BA9 | 58,713 | −2.985 | 2.84E-03 | 25,776 | −4.364 | 1.28E-05 | 32,937 | −0.124 | 9.01E-01 |
| ZNF295−AS1 | Minor salivary gland | 58,713 | −2.882 | 3.96E-03 | 25,776 | −3.91 | 9.23E-05 | 32,937 | −0.389 | 6.98E-01 |
| KAT6B | Cells cultured fibroblasts | 58,624 | 2.842 | 4.49E-03 | 25,687 | 3.928 | 8.58E-05 | 32,937 | 0.323 | 7.47E-01 |
| SPATA6L | Brain cortex | 58,713 | 2.832 | 4.63E-03 | 25,776 | 4.27 | 1.95E-05 | 32,937 | 0.003 | 9.98E-01 |
| SUDS3 | Esophagus mucosa | 58,713 | 2.733 | 6.28E-03 | 25,776 | 4.169 | 3.07E-05 | 32,937 | −0.039 | 9.69E-01 |
| TMCC3 | Brain cortex | 58,713 | −2.687 | 7.22E-03 | 25,776 | −4.329 | 1.50E-05 | 32,937 | 0.243 | 8.08E-01 |
| HSPA2 | Colon sigmoid | 58,175 | 2.521 | 1.17E-02 | 25,238 | 4.071 | 4.68E-05 | 32,937 | −0.213 | 8.31E-01 |
| RRS1 | Heart left ventricle | 58,713 | −2.152 | 3.14E-02 | 25,776 | −3.921 | 8.84E-05 | 32,937 | 0.595 | 5.52E-01 |
| TRHDE | Uterus | 58,537 | −2.11 | 3.48E-02 | 25,600 | −3.886 | 1.02E-04 | 32,937 | 0.612 | 5.40E-01 |
| LINC02664 | Artery tibial | 58,624 | 2.036 | 4.17E-02 | 25,687 | 4.385 | 1.16E-05 | 32,937 | −1.156 | 2.48E-01 |
| ADAMTSL3 | Brain cortex | 58,713 | 2.02 | 4.34E-02 | 25,776 | 3.949 | 7.84E-05 | 32,937 | −0.797 | 4.25E-01 |
| SH3GLB1 | Adrenal gland | 58,713 | 1.89 | 5.88E-02 | 25,776 | 3.91 | 9.25E-05 | 32,937 | −0.935 | 3.50E-01 |
False discovery rate adjusted genome-wide significance: p-value < 1.02 × 10−4.