Table 2.
The genes with significant effect independent to nearby known LOAD SNPs.
| Unadjusted model | Adjusted for SNP | Adjusted for gene | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Known LOAD SNP | Genes | Tissue | N | Z | p-value | Z | p-value | Z | p-value |
| APOE (rs429358); APOE (rs7412); CD33 (rs3865444) | LILRA5 | Lung | 21,924 | −5.301 | 1.15E-07 | −4.903 | 9.43E-07 | −5.358 | 8.43E-08 |
| BIN1 (rs6733839) | TMEM163 | Thyroid | 25,776 | −4.163 | 3.14E-05 | −4.177 | 2.95E-05 | −4.141 | 3.46E-05 |
| CELF1 (rs10838725) | C1QTNF4 | Brain cerebellar hemisphere | 25,776 | 4.397 | 1.10E-05 | 4.055 | 5.01E-05 | 4.115 | 3.87E-05 |
| FAM180B | Artery coronary | 25,776 | −4.504 | 6.67E-06 | −4.13 | 3.64E-05 | −4.317 | 1.58E-05 | |
| KBTBD4 | Kidney cortex | 25,776 | 3.996 | 6.45E-05 | 3.911 | 9.19E-05 | 3.803 | 0.0001431 | |
| MTCH2 | Skin sun-exposed lower leg | 25,776 | −4.245 | 2.19E-05 | −3.969 | 7.23E-05 | −3.783 | 0.000155 | |
| NDUFS3 | Cells cultured fibroblasts | 25,776 | 4.261 | 2.03E-05 | 3.899 | 9.64E-05 | 4.323 | 1.54E-05 | |
| PSMC3 | Cells cultured fibroblasts | 25,776 | −4.263 | 2.01E-05 | −3.89 | 1.00E-04 | −4.3 | 1.71E-05 | |
| PTPRJ | Brain cortex | 25,776 | 4.356 | 1.32E-05 | 4.274 | 1.92E-05 | 3.834 | 0.0001259 | |
| RAPSN | Stomach | 25,776 | 4.519 | 6.23E-06 | 4.205 | 2.61E-05 | 4.39 | 1.13E-05 | |
| SLC39A13 | Adipose visceral omentum | 25,776 | −4.279 | 1.88E-05 | −3.903 | 9.49E-05 | −4.771 | 1.84E-06 | |
| SORL1(rs11218343) | SIK2 | Brain cerebellar hemisphere | 25,776 | 4.462 | 8.14E-06 | 4.44 | 9.00E-06 | NA | NA |