Table 4.
Partitioned of the SNP-based heritability of LOAD.
| Category | SNPs (%) | h2 (%) | SE | Enrichmenta | SE | p-value |
|---|---|---|---|---|---|---|
| ALL SNPs | 100.0 | 100.0 | 0.1% | 1 | ||
| AD genes | 7.1 | 60.9 | 11.4% | 8.62 | 1.61 | 1.3E–04 |
| APOE region | 0.5 | 16.1 | 12.7% | 32.02 | 25.18 | 0.2474 |
| Non-APOE region | 6.6 | 44.8 | 6.5% | 6.83 | 0.99 | 1.9E–19 |
| Brain tissue | 4.5 | 47.4 | 10.1% | 10.63 | 2.27 | 3.9E–04 |
| Blood tissue | 2.7 | 43.1 | 12.1% | 15.91 | 4.46 | 4.7E–03 |
| Previous GWAS | 0.008 | 16.8 | 7.4% | 2039.62 | 900.05 | 0.0189 |
The “All SNPs” category used all available SNPs to estimate the heritability of LOAD, and defines 100% of the SNP-based heritability; AD genes used all SNPs located within ±1 Mb of our 216 identified AD genes; previous GWAS used 22 SNPs, which were used to generate an optimal polygenic risk score model [60], and their surrounding SNPs within ±5 Kb.
aEnrichment = Proportion of heritability/proportion of SNPs