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. 2021 Dec 6;11:23510. doi: 10.1038/s41598-021-02829-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The distributions of the coefficient of variation (CV) of cerebral blood volume (BV) and the decrease of cerebral StO2 (de-StO2). Changes in CV of BV and de-StO2 are correlated as shown in (A). The box plot suggests the outliers of CV of BV are larger than 3% and the cut-off 3% is marked with the dash line in its distribution (B). Similarly, the cut-off for outliers is 8.7% as shown in the box plot of de-StO2 and it is marked with the dash line in the distribution (C).