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. 2021 Dec 6;7:376. doi: 10.1038/s41420-021-00771-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Potential target miRNAs of miR-512-5p were predicted by databases and presented in Venn diagram. b RT-qPCR was conducted to evaluate the expression of miR-512-5p in BC cells transfected with si-NC, si-circRPPH1, LV-vector or LV-circRPPH1. c The correlation between circRPPH1 and miR-512-5p in BC tissues was analyzed by RT-qPCR (N = 40). d Putative binding sites between circRPPH1 and miR-512-5p were predicted. Plasmids containing WT (up) or MUT (down) sequences of the putative binding sites were constructed. e Dual-luciferase reporter assay was performed to validate that circRPPH1 could directly bind to miR-512-5p. f The enrichment of miR-512-5p was detected after immunoprecipitation with AGO2 in RIP assay. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.