Table 1.
List of somatic mutations in the 55 gastric cancers with current H. pylori infection.
| Sample | Gene | Coverage | Variant allele frequency | Nucleotide change | Amino acid change |
|---|---|---|---|---|---|
| B-GC1 | TP53 | 3157 | 30.6 | c.818G>A | p.Arg273His |
| B-GC3 | SMAD4 | 9192 | 13.2 | c.1525T>G | p.Trp509Gly |
| TP53 | 4942 | 30.3 | c.857A>T | p.Glu286Val | |
| B-GC8 | No mutation | ||||
| B-GC11 | No mutation | ||||
| B-GC12 | No mutation | ||||
| B-GC14 | No mutation | ||||
| B-GC15 | CTNNB1a | 4389 | 79.7 | c.101G>A | p.Gly34Glu |
| B-GC16 | TP53 | 5638 | 31.6 | c.818G>A | p.Arg273His |
| B-GC17 | NRAS | 5643 | 29.2 | c.34G>T | p.Gly12Cys |
| FBXW7 | 6577 | 28.4 | c.1514G>A | p.Arg505His | |
| FBXW7 | 4646 | 21.9 | c.1394G>A | p.Arg465His | |
| B-GC19 | TP53 | 6252 | 14.8 | c.818G>A | p.Arg273His |
| B-GC22 | TP53 | 5911 | 38.0 | c.844C>T | p.Arg282Trp |
| B-GC23 | No mutation | ||||
| B-GC27 | ERBB4 | 9636 | 25.1 | c.1817A>G | p.Lys606Arg |
| B-GC33 | TP53 | 4987 | 63.1 | c.743G>A | p.Arg248Gln |
| B-GC34 | No mutation | ||||
| B-GC35 | No mutation | ||||
| B-GC37 | No mutation | ||||
| B-GC38 | No mutation | ||||
| B-GC39 | No mutation | ||||
| B-GC52 | No mutation | ||||
| B-GC56 | No mutation | ||||
| B-GC63 | SMAD4 | 1269 | 34.8 | c.1082G>A | p.Arg361His |
| B-GC64 | No mutation | ||||
| B-GC66 | PIK3CAa | 618 | 15.7 | c.1624G>A | p.Glu542Lys |
| KRASa,b | 336 | 22.3 | c.34G>A | p.Gly12Ser | |
| KRASa,b | 333 | 18.0 | c.35G>A | p.Gly12Asp | |
| B-GC70 | No mutation | ||||
| B-GC71 | TP53 | 1066 | 66.8 | c.659A>G | p.Tyr220Cys |
| B-GC73 | No mutation | ||||
| B-GC74 | TP53 | 1520 | 55.6 | c.853G>A | p.Glu285Lys |
| B-GC75 | TP53 | 602 | 51.3 | c.536A>G | p.His179Arg |
| B-GC77 | TP53 | 566 | 43.8 | c.404G>A | p.Cys135Tyr |
| B-GC80 | TP53 | 546 | 43.4 | c.536A>G | p.His179Arg |
| FBXW7 | 1063 | 46.8 | c.1393C>T | p.Arg465Cys | |
| B-GC81 | No mutation | ||||
| B-GC83 | GNAS | 222 | 12.6 | c.2531G>A | p.Arg844His |
| B-GC85 | No mutation | ||||
| B-GC86 | TP53 | 1664 | 59.1 | c.818G>T | p.Arg273Leu |
| B-GC87 | TP53 | 569 | 31.6 | c.388C>G | p.Leu130Val |
| B-GC88 | TP53 | 675 | 52.6 | c.524G>A | p.Arg175His |
| ERBB4 | 988 | 53.7 | c.719G>A | p.Gly240Glu | |
| B-GC90 | TP53 | 1833 | 20.7 | c.818G>A | p.Arg273His |
| B-GC92 | No mutation | ||||
| B-GC95 | No mutation | ||||
| B-GC96 | PIK3CAa | 806 | 12.3 | c.1633G>A | p.Glu545Lys |
| B-GC97 | No mutation | ||||
| B-GC98 | No mutation | ||||
| S2 | TP53 | 496 | 34.1 | c.581T>G | p.Leu194Arg |
| S4 | TP53 | 438 | 74.2 | c.581T>G | p.Leu194Arg |
| S13 | TP53 | 70 | 15.7 | c.478A>G | p.Met160Val |
| ERBB2a | 482 | 23.9 | c.2264T>C | p.Leu755Ser | |
| S17 | No mutation | ||||
| S19 | No mutation | ||||
| S20 | No mutation | ||||
| S21 | No mutation | ||||
| S22 | No mutation | ||||
| S23 | TP53 | 565 | 67.8 | c.537T>A | p.His179Gln |
| S36 | TP53 | 1142 | 34.9 | c.524G>A | p.Arg175His |
| S43 | TP53 | 239 | 74.9 | c.1024C>T | p.Arg342Ter |
| S124 | No mutation |
aActivated oncogene mutation.
bThese mutations did not exist on the same allele.