Table 2.

The association of obesity-related variants and regional brain volumes.

S.N	SNP-EA	Gene	Class	N	EAF	Beta	SE	P.value	Brain
1	rs1038088-G	SSH2	BMI+	19,997	0.524	17.659	3.041	6.39 × 10−9	Volume of grey matter in Subcallosal Cortex (left)
2	rs1038088-G	SSH2	BMI+	19,997	0.524	15.501	2.754	1.81 × 10−8	Volume of grey matter in Subcallosal Cortex (right)
3	rs11727676-C	HHIP	WHR + BMI-	19,997	0.094	68.706	9.471	4.03 × 10−13	Volume of grey matter in Intracalcarine Cortex (left)
4	rs11727676-C	HHIP	WHR + BMI-	19,997	0.094	73.953	8.98	1.79 × 10−16	Volume of grey matter in Intracalcarine Cortex (right)
5	rs11727676-C	HHIP	WHR + BMI-	19,997	0.094	129.419	19.425	2.69 × 10−11	Volume of grey matter in Occipital Pole (right)
6	rs12321904-T	MMAB	BMI+	19,997	0.492	−13.264	2.32	1.08 × 10−8	Volume of grey matter in VI Cerebellum (vermis)
7	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	−199.145	28.303	1.97 × 10−12	Volume of grey matter in Precentral Gyrus (left)
8	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	−163.696	25.392	1.14 × 10−10	Volume of grey matter in Postcentral Gyrus (left)
9	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	−136.248	24.761	3.74 × 10−8	Volume of grey matter in Postcentral Gyrus (right)
10	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	−89.495	14.23	3.19 × 10−10	Volume of grey matter in Angular Gyrus (left)
11	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	71.89	12.789	1.90 × 10−8	Volume of grey matter in Caudate (left)
12	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	83.676	13.419	4.49 × 10−10	Volume of grey matter in Caudate (right)
13	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	153.62	7.931	1.37 × 10−83	Volume of grey matter in Putamen (left)
14	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	171.967	8.599	5.68 × 10−89	Volume of grey matter in Putamen (right)
15	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	40.955	1.901	6.22 × 10−103	Volume of grey matter in Ventral Striatum (left)
16	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	39.955	1.891	3.92 × 10−99	Volume of grey matter in Ventral Striatum (right)
17	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	116.801	14.497	7.82 × 10−16	Volume of grey matter in Brain-Stem
18	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	50.719	5.269	6.17 × 10−22	Volume of grey matter in I-IV Cerebellum (left)
19	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	40.14	5.656	1.28 × 10−12	Volume of grey matter in I-IV Cerebellum (right)
20	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	60.023	6.953	6.02 × 10−18	Volume of grey matter in V Cerebellum (left)
21	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	41.691	6.751	6.59 × 10−10	Volume of grey matter in V Cerebellum (right)
22	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	127.266	17.742	7.33 × 10−13	Volume of grey matter in VI Cerebellum (left)
23	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	131.29	17.427	4.93 × 10−14	Volume of grey matter in VI Cerebellum (right)
24	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	86.683	12.276	1.65 × 10−12	Volume of grey matter in VIIIa Cerebellum (left)
25	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	25.969	3.17	2.56 × 10−16	Volume of grey matter in VIIIa Cerebellum (vermis)
26	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	86.785	12.98	2.30 × 10−11	Volume of grey matter in VIIIa Cerebellum (right)
27	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	104.841	9.205	4.70 × 10−30	Volume of grey matter in VIIIb Cerebellum (left)
28	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	15.109	1.585	1.57 × 10−21	Volume of grey matter in VIIIb Cerebellum (vermis)
29	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	108.063	9.964	2.11 × 10−27	Volume of grey matter in VIIIb Cerebellum (right)
30	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	95.695	7.196	2.37 × 10−40	Volume of grey matter in IX Cerebellum (left)
31	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	30.419	1.667	2.29 × 10−74	Volume of grey matter in IX Cerebellum (vermis)
32	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	104.296	7.925	1.50 × 10−39	Volume of grey matter in IX Cerebellum (right)
33	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	10.036	0.813	4.90 × 10−35	Volume of grey matter in X Cerebellum (vermis)
34	rs13107325-T	SLC39A8	BMI + WHR-	19,997	0.071	−2,366.75	379.517	4.48 × 10−10	Volume of peripheral cortical grey matter
35	rs7970350-C	HMGA2	WC + HC+	19,997	0.512	−2,883.9	484.584	2.66 × 10−9	Volume of white matter (normalised for head size)
36	rs7970350-C	HMGA2	WC + HC+	19,997	0.512	−6,084.3	1,065.68	1.13 × 10−8	Volume of grey + white matter (normalised for head size)
37	rs1481012-A	ABCG2	BMI+	19,997	0.887	18.18	3.479	1.73 × 10−7	Volume of pallidum (left)
38	rs1538170-T	CENPW	HC+	19,997	0.454	20.454	2.758	1.20 × 10−13	Volume of grey matter in Subcallosal Cortex (right)
39	rs1538170-T	CENPW	HC+	19,997	0.454	−10.73	1.797	2.34 × 10−9	Volume of grey matter in Planum Polare (left)
40	rs1538170-T	CENPW	HC+	19,997	0.454	−10.793	1.819	2.94 × 10−9	Volume of grey matter in Planum Polare (right)
41	rs1538170-T	CENPW	HC+	19,997	0.454	−68.284	11.407	2.15 × 10−9	Volume of grey matter in Occipital Pole (right)
42	rs1538170-T	CENPW	HC+	19,997	0.454	−3,882.67	532.891	3.19 × 10−13	Volume of peripheral cortical grey matter (normalised for head size)
43	rs1538170-T	CENPW	HC+	19,997	0.454	−4,892.74	667.287	2.26 × 10−13	Volume of grey matter (normalised for head size)
44	rs1538170-T	CENPW	HC+	19,997	0.454	−3,319.8	480.06	4.67 × 10−12	Volume of white matter (normalised for head size)
45	rs1538170-T	CENPW	HC+	19,997	0.454	−8,212.59	1,055.32	7.13 × 10−15	Volume of grey + white matter (normalised for head size)
46	rs17019336-T	HHIP-AS1	BMI+	19,997	0.762	−32.702	6.253	1.69 × 10−7	Volume of grey matter in Intracalcarine Cortex (right)
47	rs1727294-A	PITPNM2	HC+	19,997	0.212	−3,245.01	584.4	2.81 × 10−8	Volume of white matter (normalised for head size)
48	rs1876829-C	CRHR1	WHR+	19,997	0.223	126.725	23.764	9.67 × 10−8	Volume of grey matter in Frontal Pole (right)
49	rs1876829-C	CRHR1	WHR+	19,997	0.223	31.713	5.943	9.49 × 10−8	Volume of grey matter in Insular Cortex (left)
50	rs1876829-C	CRHR1	WHR+	19,997	0.223	13.833	2.419	1.08 × 10−8	Volume of grey matter in Parahippocampal Gyrus (left)
51	rs1876829-C	CRHR1	WHR+	19,997	0.223	4,471.49	637.428	2.30 × 10−12	Volume of peripheral cortical grey matter (normalised for head size)
52	rs1876829-C	CRHR1	WHR+	19,997	0.223	1,401.02	231.601	1.46 × 10−9	Volume of peripheral cortical grey matter
53	rs1876829-C	CRHR1	WHR+	19,997	0.223	5,289.25	798.307	3.46 × 10−11	Volume of grey matter (normalised for head size)
54	rs1876829-C	CRHR1	WHR+	19,997	0.223	1,458.67	246.928	3.48 × 10−9	Volume of grey matter
55	rs1876829-C	CRHR1	WHR+	19,997	0.223	−1,455.13	224.861	9.72 × 10−11	Volume of white matter
56	rs329124-A	JADE2	BMI+	19,997	0.577	−5.597	0.995	1.83 × 10−8	Volume of grey matter in Ventral Striatum (left)
57	rs329124-A	JADE2	BMI+	19,997	0.577	−6.135	0.988	5.42 × 10−10	Volume of grey matter in Ventral Striatum (right)
58	rs3744017-A	TRIM47	BMI+	19,997	0.188	49.258	8.359	3.79 × 10−9	Volume of grey matter in Caudate (left)
59	rs3744017-A	TRIM47	BMI+	19,997	0.188	53.697	8.771	9.24 × 10−10	Volume of grey matter in Caudate (right)
60	rs591939-G	NAGLU	WHR+	19,997	0.248	−26.011	4.724	3.66 × 10−8	Volume of grey matter in Putamen (left)
61	rs591939-G	NAGLU	WHR+	19,997	0.248	−28.603	5.125	2.39 × 10−8	Volume of grey matter in Putamen (right)
62	rs6857-C	NECTIN2	BMI + WHR + WC+	19,997	0.832	−39.875	7.068	1.68 × 10−8	Volume of grey matter in Intracalcarine Cortex (right)
63	rs1243188-C	MLLT10	WHR + BMI+	19,997	0.3	−1,428.21	191.636	9.14 × 10−14	Volume of ventricular cerebrospinal fluid (normalised for head size)
64	rs1243188-C	MLLT10	WHR + BMI+	19,997	0.3	−1,186.24	162.27	2.67 × 10−13	Volume of ventricular cerebrospinal fluid
65	rs1243188-C	MLLT10	WHR + BMI+	19,997	0.3	1,186.21	162.27	2.67 × 10−13	Volume of grey + white matter
66	rs798502-A	GNA12	WC + HC+	19,997	0.699	32.16	5.455	3.74 × 10−9	Volume of grey matter in Insular Cortex (left)
67	rs798502-A	GNA12	WC + HC+	19,997	0.699	36.184	5.515	5.34 × 10−11	Volume of grey matter in Insular Cortex (right)
68	rs806794-A	H2BC7	HC + WC+	19,997	0.729	−26.161	5.019	1.87 × 10−7	Volume of grey matter in Putamen (right)
69	rs806794-A	H2BC7	HC + WC+	19,997	0.729	−33.395	6.158	5.85 × 10−8	Volume of thalamus (left)

SNP-EA, SNP and effect allele; Gene, genes mapping using genomic position; Class, The SNP and its LD variants-related obesity traits; N, sample number; EAF, frequency of effect allele; Beta, effect size of effect allele; P.value, the significance level of each variant.

BMI is the body mass index, WHR is the waist to hip ratio, WC is the waist ratio, HC is the hip raito.