Fig. 4.

Correlation analysis between the pattern expression scores and the pathological biomarkers. The ARADRP was identified from the combined two cohorts and a correlation analysis was performed between the pattern expression scores and the AV45 SUVRs (A), CSF p-tau levels (B), and CSF t-tau levels (C) in the ADNI cohort. Abbreviations: AV45, [¹⁸F]florbetapir; SUVR, standardized uptake value ratio; Aβ, β-amyloid; NCs, cognitively normal controls; ARADRP, at-risk Alzheimer’s disease-related metabolic pattern; ADNI, Alzheimer’s Disease Neuroimaging Initiative; CSF, cerebrospinal fluid; p-tau, phosphorylated tau.