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. 2021 Dec 6;12(12):1134. doi: 10.1038/s41419-021-04418-9

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© The Author(s) 2021, corrected publication 2022

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Fig. 4 — A WB revealed that stiffness-induced AKT phosphorylation at S473. B AKT inhibitor MK2206 reduced p-AKT(S473), total E2F3, and HSC activation markers, α-SMA, CTGF level of HSCs. Data represent multiple repeats with similar results. C IF showed that MK2206 suppressed stiffness-mediated E2F3 overexpression and activation of HSCs. D CD36 inhibitor SSO reduced p-AKT, and E2F3 levels of HSCs.