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. 2021 Dec 6;12(12):1134. doi: 10.1038/s41419-021-04418-9

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© The Author(s) 2021, corrected publication 2022

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Fig. 8 — A Livers of olive oil-treated mice or CCl4-treated mice were collected for WB. CCl4 treatment upregulated α-SMA and E2F3 in murine liver. Densitometry is shown on the bottom. *p < 0.05 by t-test. B E2F3 F/F cre mice and E2F3 + / + cre mice were treated with CCl4 for 6 weeks and their livers were. collected for IF for HSC activation markers and collagen I. Quantitative IF data are shown on the right. E2F3 F/F cre livers showed reduced α-SMA and collagen I level, as compared to E2F3 + / + cre livers after CCl4 treatment. *p < 0.05 by t-test. C CCl4-treated livers were subjected to WB and densitometry data were shown on the bottom. CCl4-treated E2F3 F/F cre livers contained reduced α-SMA and collagen I level as compared to E2F3 + / + cre livers. *p < 0.05 by t-test. D, E Sirius red staining and Trichrome staining of liver sections are shown. Collagen deposition was reduced in CCl4-treated E2F3 F/F cre livers as compared to E2F3 + / + cre livers. *p < 0.05 by t-test.