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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Biochem Pharmacol. 2021 Jun 7;196:114647. doi: 10.1016/j.bcp.2021.114647

Fig. 3.

Fig. 3.

Sterol agonists of SMO. Class I sterols do not require CRD as they can activate SMOΔCRD when delivered as MCD inclusion complexes, although cholesterol and 24(S),25-epoxycholesterol can also bind CRD. Class II sterols only bind SMO CRD and can activate full-length SMO but not SMOΔCRD regardless of whether they are added from ethanol stocks or as MCD complexes. When a class I and a class II sterol are added together from ethanol stocks, a synergistic (more than additive) effect is observed. See Fig. 4 for biosynthesis of individual sterols (indicated by numbers).