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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Biochem Pharmacol. 2021 Jun 7;196:114647. doi: 10.1016/j.bcp.2021.114647

Fig. 5.

Fig. 5.

Formation mechanism of the SMO antagonist DHCEO. Besides cholesterol, which has a positive effect, none of the other sterols shown affect Hh pathway (unpublished observations). Whether the last step of DHCEO synthesis is reversible and which enzymes are responsible are not known.