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. 2021 Dec 6;11:23514. doi: 10.1038/s41598-021-02954-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Associations between genital cytokines and mucosal IgG1 (A), IgG2 (B), IgG3 (C), IgG4 (D), IgM (E) and IgA (F). β-coefficients and p-values were determined using multivariable linear mixed models with a random effect of the matched pairs (N = 132). The multivariable models were adjusted for age, HSV-2 status, the number of vaginal sex acts, contraceptive method, condom use, tenofovir use and HIV infection status. β-coefficients are indicated by shaded circles and error bars indicate 95% confidence intervals. P-values < 0.05 are represented by *, and those p-values that are significant after multiple comparisons adjustment are represented by #.

Associations between genital cytokines and mucosal IgG1 (A), IgG2 (B), IgG3 (C), IgG4 (D), IgM (E) and IgA (F). β-coefficients and p-values were determined using multivariable linear mixed models with a random effect of the matched pairs (N = 132). The multivariable models were adjusted for age, HSV-2 status, the number of vaginal sex acts, contraceptive method, condom use, tenofovir use and HIV infection status. β-coefficients are indicated by shaded circles and error bars indicate 95% confidence intervals. P-values < 0.05 are represented by *, and those p-values that are significant after multiple comparisons adjustment are represented by #.