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. 2021 Dec 6;11:23452. doi: 10.1038/s41598-021-02282-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The holistic miRNA-target interaction maps were constructed, and key modules were identified. To investigate the role of differentially expressed miRNAs, the validated targets were identified, and the interaction networks were constructed with the differentially expressed miRNAs and their validated targets in the cortex (a) and medulla (b). Four modules in the cortex (I-IV) and one in medulla (V) networks were found, which potentially represent key interactions (c).