Table 2.
Prevalence and odds ratio of inflammatory bowel disease (IBD), microscopic colitis, precancerous polyps, colorectal cancer and celiac disease in patients with IBS and matched controls as well as IBS and sibling comparators.
| Group | N events (%) IBS | Comparators | Odds ratio* (95%CI) | Odds ratio** (95%CI) | Sibling comparatOdds ratio*** (95%CI) |
|---|---|---|---|---|---|
| Overall | |||||
| IBD | 341 (1.6%) | 5 796 (5.9%) | 0.22 (0.20–0.25) | 0.21 (0.19–0.24) | 0.32 (0.19–0.53 |
| Colorectal cancer | 166 (0.8%) | 6 166 (6.3%) | 0.10 (0.09–0.12) | 0.17 (0.14–0.20) | 0.13 (0.05–0.37 |
| Microscopic colitis | 640 (2.9%) | 1 649 (1.7%) | 1.88 (1.71–2.06) | 1.77 (1.61–1.95) | 2.30 (1.30–4.08 |
| Precancerous polyps | 902 (4.1%) | 12 635 (13.0%) | 0.28 (0.26–0.30) | 0.28 (0.26–0.30) | 0.23 (0.16–0.33 |
| Non advanced | 669 (3.0%) | 7 995 (8.2%) | 0.35 (0.32–0.38) | 0.34 (0.32–0.37) | 0.23 (0.15–0.36 |
| Advanced | 249 (1.1%) | 5 042 (5.2%) | 0.21 (0.18–0.24) | 0.23 (0.20–0.26) | 0.34 (0.19–0.60 |
| Celiac disease | 192 (1.9%) | 1 568 (3.4%) | 0.54 (0.47–0.63) | 0.54 (0.47–0.63) | 0.47 (0.19–1.18 |
| Age <50y | |||||
| IBD | 243 (1.8%) | 4 902 (8.5%) | 0.17 (0.15–0.20) | 0.17 (0.15–0.20) | 0.22 (0.11–0.45 |
| Colorectal cancer | 24 (0.2%) | 981 (1.7%) | 0.10 (0.06–0.14) | 0.21 (0.13–0.34) | - |
| Microscopic colitis | 203 (1.5%) | 782 (1.4%) | 1.18 (1.01–1.38) | 1.16 (0.99–1.36) | 14.67 (0.37–578.5 |
| Precancerous polyps | 229 (1.7%) | 3 071 (5.3%) | 0.31 (0.27–0.35) | 0.32 (0.28–0.37) | 0.19 (0.07–0.50 |
| Non advanced | 177 (1.3%) | 2 171 (3.8%) | 0.35 (0.30–0.41) | 0.35 (0.30–0.41) | 0.17 (0.05–0.59 |
| Advanced | 54 (0.4%) | 961 (1.7%) | 0.23 (0.18–0.31) | 0.26 (0.19–0.34) | 0.83 (0.18–3.74 |
| Celiac disease | 136 (2.0%) | 1 300 (4.2%) | 0.45 (0.38–0.54) | 0.46 (0.38–0.55) | 0.27 (0.07–1.00 |
| Age ≥50y | |||||
| IBD | 98 (1.2%) | 894 (2.3%) | 0.51 (0.42–0.63) | 0.46 (0.38–0.58) | 0.55 (0.13–2.30 |
| Colorectal cancer | 142 (1.7%) | 5 185 (13.1%) | 0.10 (0.09–0.12) | 0.16 (0.13–0.20) | 0.14 (0.04–0.44 |
| Microscopic colitis | 437 (5.3%) | 867 (2.2%) | 2.58 (2.29–2.91) | 2.36 (2.09–2.66) | 2.24 (1.14–4.42 |
| Precancerous polyps | 673 (8.1%) | 9 564 (24.1%) | 0.27 (0.25–0.29) | 0.27 (0.25–0.29) | 0.20 (0.13–0.33 |
| Non advanced | 492 (5.9%) | 5 824 (14.7%) | 0.36 (0.32–0.39) | 0.34 (0.31–0.37) | 0.25 (0.15–0.42 |
| Advanced | 195 (2.4%) | 4 081 (10.3%) | 0.20 (0.18–0.24) | 0.22 (0.19–0.25) | 0.26 (0.13–0.55 |
| Celiac disease | 56 (1.8%) | 268 (1.8%) | 1.04 (0.78–1.39) | 1.00 (0.74–1.34) | 0.47 (0.04–5.29 |
*
Conditioned on matching set (age, sex, county, and calendar period)
**
Conditioned on matching set and further adjusted for education and baseline medical comorbidities (cancer, diabetes, CVD, and neurologic disease).
***
Conditioned on matching set and further adjusted for age, sex, education and baseline medical comorbidities (cancer, diabetes, CVD, and neurologic disease).