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. Author manuscript; available in PMC: 2022 Dec 13.
Published in final edited form as: Angew Chem Int Ed Engl. 2021 Oct 6:10.1002/anie.202108848. doi: 10.1002/anie.202108848

Figure 1.

Figure 1.

Structures of cereblon binders and related PROTACs. (A) Surface representation of G. gallus cereblon (gray: carbon; blue: nitrogen) in complex with thalidomide 1a (green sticks), PDB: 4CI1, model structure of phenyl glutarimide 2a (magenta sticks), and water molecule (red sphere). (B) Chemical structures of immunomodulatory drugs (IMiDs), phenyl glutarimide (PG), their analogues and related PROTACs. (C) Small molecule crystal structure of the active (R)-2b enantiomer (yellow) superimposed over the (S)-2b enantiomer (faded ball-and-stick model).