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. 2021 Aug 28;10(17):e020589. doi: 10.1161/JAHA.120.020589

Figure 5. MicroRNA‐96 inhibits inflammatory responses and fibrosis caused by doxorubicin‐induced myocardial toxicity.

Figure 5

A through C, The serum levels of tumor necrosis factor‐α, interleukin‐6, and interleukin‐1β. D, The morphology of the mouse myocardium. E, Fibrous changes in the myocardium. F, Integrated optical density of collagen fibers. G, The expression of soluble suppression of tumorigenesis‐2 in the myocardium; 8 rats for each group. Exo+inhibitor indicates exosome plus inhibitor; Exo+mimic, exosome plus mimic; Exo+miR‐96, exosome plus microRNA‐96; IL‐1β, interleukin‐1β; IL‐6, interleukin‐6; IOD, integrated optical density; NC, negative control; sST2, soluble suppression of tumorigenesis‐2; and TNF‐α, tumor necrosis factor‐α. † P<0.05, compared with the exosome+mimic NC group; and § P<0.05, compared with the exosome+inhibitor NC group; data were presented as mean±SD; data were analyzed using 1‐way ANOVA and the Tukey test was applied for post hoc multiple comparisons.