Figure 6. The Rac1/nuclear factor‐κB signaling pathway is activated in the myocardium with doxorubicin‐induced toxicity.

A and B, The expression of Rac1 in the myocardium measured by quantitative real time polymerase chain reaction and Western blotting. C, the levels of p‐IKKα, p‐IKKβ, p‐IκBα, and p‐p65 measured by Western blotting; 8 rats for each group. Exo+inhibitor indicates exosome plus inhibitor; Exo+mimic, exosome plus mimic; Exo+miR‐96, exosome plus microRNA‐96; and negative control (NC). *P<0.05, compared with the normal group; ^‡ P<0.05, compared with the doxorubicin group; ^† P<0.05, compared with the exosome+mimic NC group; and ^§ P<0.05, compared with the exosome+inhibitor NC group; data were presented as mean±SD; data were analyzed using 1‐way ANOVA and the Tukey test was applied for post hoc multiple comparisons.