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. 2021 Sep 2;10(17):e020895. doi: 10.1161/JAHA.121.020895

Figure 5. Role of Hif‐1α (hypoxia‐inducible factor 1‐α) in CC‐8 (cleaved caspase‐8), inflammation, and matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) in the myocardial infarction (MI) border zone on day 5.

Figure 5

A, Expression of CC‐8, cleaved interleukin‐1β (cIL‐1β), Mac‐3, MMP‐2, MMP‐9, TIMP‐1, and TIMP‐2 in the MI border zone at day 5 after MI. GAPDH (glyceraldehyde 3‐phosphate dehydrogenase) was used as a loading control (CTL). B, Quantification of Western blots shown in (A); n=4 in each group. Data are shown as a ratio to CTL+MI. *P<0.05, **P<0.01 vs CTL+MI, analyzed by Student t test. caHetKO indicates cardiac‐specific Hif‐1α hetero‐knockout; and N/A indicates not applicable.