Table 1.
Clinical Comparison: MCA Laboratory Abnormality Versus POTS* Alone
|
Atypical Symptoms + Abnormal Laboratory Tests (n=29) |
% |
Normal Laboratory Evaluation or Typical Symptoms Only (n=40) |
% | P Values | |
|---|---|---|---|---|---|
| Age, y | 33 ± 10.4 | 28 ± 10.3 | <0.02 | ||
| Female sex | 28 | 93 | 38 | 95 | 0.739 |
| Palpitation | 23 | 79 | 37 | 93 | 0.108 |
| Syncope | 8 | 27 | 13 | 33 | 0.297 |
| Fatigue | 22 | 76 | 22 | 55 | 0.075 |
|
Lightheadedness /dizzy/ “brain fog” |
26 | 90 | 35 | 88 | 0.078 |
| Migraines | 12 | 41 | 5 | 13 | 0.05 |
| Depression/anxiety | 11 | 38 | 9 | 23 | 0.163 |
| Fibromyalgia | 5 | 17 | 3 | 8 | 0.212 |
| Allergy | 15 | 52 | 1 | 3 | <0.0 |
| Skin rash | 13 | 52 | 2 | 5 | <0.0 |
| Gastrointestinal symptoms | 28 | 76 | 12 | 30 | <0.0 |
MCA indicates mast cell activation; and POTS, postural orthostatic tachycardia syndrome.
*Includes patients with typical POTS symptoms only (n=15) and those with typical and atypical symptoms but with normal laboratory studies (n=25).