Table 1.
Characteristics of Participants in the Analytic Subset of the UK Biobank Study
| Characteristics | Overall | Genetic risk score percentile | P value | |
|---|---|---|---|---|
| Lower 50% | Upper 50% | |||
| No. of participants | 367 703 | 183 822 | 183 821 | … |
| Age at survey, mean (SD), y | 57.2 (8.0) | 57.2 (8.0) | 57.2 (8.0) | 0.26 |
| Women, n (%) | 198 902 (54.1) | 99 564 (54.2) | 99 307 (54.0) | 0.39 |
| Body mass index, mean (SD), kg/m2 | 27.4 (4.8) | 27.4 (4.8) | 27.3 (4.7) | <0.001 |
| Low‐density lipoprotein, mean (SD), mmol/L | 3.57 (0.87) | 3.59 (0.87) | 3.55 (0.87) | <0.001 |
| HbA1c, mean (SD), mmol/mol | 35.9 (6.4) | 35.9 (6.4) | 35.9 (6.5) | 0.10 |
| History of diabetes mellitus at recruitment, n (%) | 16 927 (4.6) | 8082 (4.4) | 8843 (4.8) | <0.001 |
| Physical activity, mean (SD), MET min/wk | 2660 (2710) | 2650 (2710) | 2669 (2709) | 0.06 |
| Deaths, n (%) | 8033 (2.2) | 3925 (2.1) | 4105 (2.2) | 0.04 |
| Cardiovascular events, n (%) | 7145 (1.9) | 3291 (1.8) | 3853 (2.1) | <0.001 |
| Cardiovascular events (fatal), n (%) | 1422 (0.4) | 682 (0.4) | 740 (0.4) | 0.12 |
| Cardiovascular events (nonfatal), n (%) | 5723 (1.6) | 2609 (1.4) | 3113 (1.7) | <0.001 |
| Cerebrovascular events (fatal), n (%) | 2714 (0.7) | 1217 (0.7) | 1497 (0.8) | <0.001 |
| Current smokers, n (%) | 37 866 (10.3) | 19 099 (10.4) | 18 763 (10.2) | 0.07 |
| Current alcohol drinkers, n (%) | 342 797 (93.4) | 171 486 (93.4) | 171 260 (93.3) | 0.25 |
| Participants taking antihypertensives, n (%) | 74 556 (20.4) | 29 841 (16.4) | 44 702 (24.5) | <0.001 |
| Systolic blood pressure, mean (SD), mm Hg | 137.7 (18.6) | 135.6 (18.2) | 139.7 (18.8) | <0.001 |
| Diastolic blood pressure, mean (SD), mm Hg | 82.0 (10.1) | 81.1 (10.0) | 82.8 (10.2) | <0.001 |
Genetic risk score was calculated from 256 variants previously associated with a blood pressure trait at P<5×10−8 in data from the International Consortium for Blood Pressure, excluding UK Biobank participants. Physical activity is measured in MET minutes per week, and is taken from Data Field 22 040. HbA1c indicates glycated hemoglobin; and MET, metabolic equivalent task.