FIGURE 1.

miR‐125a‐5p promoted gastric cancer (GC) growth and invasion. (A) miR‐125a‐5p expression in the gastric epithelial cell line GES‐1 and the GC cell lines AGS, SGC‐7901, BGC‐823, MGC‐803, MKN‐45, N87, SNU‐5, and KATO‐III was detected using real‐time qRT‐PCR. (B) KATO‐III and N87 cells were transfected with miR‐125a‐5p mimics and inhibitors at a final concentration of 50 nM. miR‐125a‐5p expression was detected using real‐time qRT‐PCR at 48 h after transfection. (C) Cell viability was evaluated using colony formation assays at the indicated times after transfection. (D) The effects of miR‐125a‐5p antagomir on N87 tumor growth were evaluated using the growth curve and tumor weights. (E) Invasive capacity was evaluated in cells treated with miR‐125a‐5p mimics and inhibitors as described in B. Blank, blank control; NC, negative control; *p < 0.05; **p < 0.01; ***p < 0.001