TABLE 2.

Results of correlation analysis between metabolites and clinical parameters (p < 0.05)

Metabolites	Super Class	UPLC‐HRMS			Correlation
		VIP	p value	FC	r	p value
Newborn birth weight
PC(14:0/18:0)	Lipids and lipid‐like molecules	5.12	0.01	0.81	−0.4128	0.0189
Imidazolepropionic acid	Organoheterocyclic compounds	2.27	<0.0001	1.66	0.5530	<0.000110
6‐Acetyl−2,2‐dimethyl−2H−1‐benzopyran	Organoheterocyclic compounds	2.01	<0.0001	1.25	0.4933	<0.000141
Armillarin	Lipids and lipid‐like molecules	1.05	0.04	1.14	−0.4018	0.0227
Maternal age
Oleic Acid	Lipids and lipid‐like molecules	5.20	0.02	1.30	−0.3750	0.0344
Linoleic acid	Lipids and lipid‐like molecules	5.07	0.01	1.27	−0.4331	0.0133
MG(18:0/0:0/0:0)	Lipids and lipid‐like molecules	3.62	<0.0001	0.87	0.3697	0.0373
Ethyl isopropyl disulfide	Organosulfur compounds	3.35	<0.0001	1.21	−0.4103	0.0197
1‐Phenyl−1,2‐propanedione	Benzenoids	2.38	<0.0001	1.37	−0.4434	0.0110
Aminocaproic acid	Lipids and lipid‐like molecules	2.25	<0.0001	1.32	−0.4199	0.0167
Phenylpyruvic acid	Benzenoids	2.04	<0.0001	1.37	−0.3679	0.0383
Gestational age of delivery
2‐Furanmethanol	Organoheterocyclic compounds	1.41	<0.0001	1.23	−0.4710	<0.000165
17a‐Hydroxypregnenolone	Lipids and lipid‐like molecules	1.40	<0.0001	1.53	−0.5138	<0.000126
(±)‐erythro‐Isoleucine	Organic acids and derivatives	1.26	<0.0001	1.30	−0.3541	0.0468
1‐Octene	Hydrocarbons	1.67	<0.0001	0.89	0.4769	<0.000158
Piperidine	Organoheterocyclic compounds	1.21	<0.0001	1.35	−0.4484	0.0101
L‐Carnitine	Organic nitrogen compounds	1.18	0.02	1.16	−0.4291	0.0143
Cadinene	Lipids and lipid‐like molecules	1.14	0.01	1.18	−0.4640	<0.000175
OKOHA‐PA	Lipids and lipid‐like molecules	1.04	<0.0001	1.55	−0.3888	0.0279

Abbreviations: FC, Fold change; UPLC‐HRMS, Ultra‐performance liquid chromatography‐high resolution mass spectrometry; VIP, variable influence on projection.