Table 1.
Patient demographics, family history, and neuropsychiatric medical history.
| Total JSLE patients n = 428 | NP involvement n = 107< | No NP involvement n = 321 | p value | Early NP involvement n = 52 | Late NP involvement n = 55 | p value | |
|---|---|---|---|---|---|---|---|
| Age at diagnosis (mean) in years (range) | 12.2 (0.1–17.9) | 12 (0.7–17.9) | 12.2 (0.1–17) | 0.64 | 11.9 (2.5–16.8) | 12.1 (0.7–17.9) | 0.71 |
| F:M ratio | 5.4:1 | 5.2:1 | 5.5:1 | 0.87 | 4.7:1 | 5.8:1 | 0.69 |
| Ethnicity | 0.90 | 0.53 | |||||
| White Caucasian | 220 (51.4%) | 57 (53.2%) | 163 (50.7%) | 25 (48%) | 32 (58.1%) | ||
| Black | |||||||
| African | 37 (8.6%) | 7 (6.5%) | 30 (9.3%) | 5 (9.6%) | 2 (3.6%) | ||
| Black Caribbean | 35 (8.1%) | 10 (9.3%) | 25 (7.7%) | 4 (7.6%) | 6 (10.9%) | ||
| East Asian | 28 (6.5%) | 7 (6.5%) | 21 (6.5%) | 3 (5.7%) | 4 (7.2%) | ||
| South Asian | 100 (23.3%) | 26 (24.2%) | 74 (23%) | 15 (28.8%) | 11 (20%) | ||
| Family history of AID | |||||||
| Any AID | 207 (48.3%) | 45 (42%) | 162 (50.4%) | 1 | 22 (42.3%) | 29 (52.7%) | 1 |
| SLE | 52 (12.1%) | 10 (9.3%) | 42 (13%) | 0.3 | 3 (5.7%) | 7 (12.7%) | 0.22 |
| CTD | 8 (1.8%) | 3 (2.8%) | 5 (1.5%) | 0.41 | 2 (3.8%) | 1 (1.8%) | 0.53 |
| Thyroid | 50 (11.6%) | 10 (9.3%) | 40 (12.4%) | 0.38 | 5 (9.6%) | 5 (9%) | 0.92 |
| IDDM | 34 (7.9%) | 9 (8.4%) | 25 (7.7%) | 0.83 | 6 (11.5%) | 4 (7.2%) | 0.67 |
| Rheumatoid Arthritis | 63 (14.7%) | 13 (12.1%) | 50 (15.5%) | 0.38 | 6 (11.5%) | 7 (12.7%9 | 0.85 |
“Early” neuropsychiatric juvenile systemic lupus erythematosus (NP-JSLE) patients had NP features at the first recorded visit. AID, Autoimmune disease; CTD, Connective Tissue Disease; IDDM, Insulin-Dependent Diabetes Mellitus. For continuous variables, Mann–Whitney U test was used; for categorical variables, Chi-square test was used.