Table 1.
GO Function Annotation of uDEGs and dDEGs Associated With NSCLC (top five).
| Category | Term | Count | % | P-value |
|---|---|---|---|---|
| uDEGs | ||||
| GOTERM_BP_DIRECT | GO:0007067∼mitotic nuclear division | 22 | 0.07753304 | 7.26E-14 |
| GOTERM_BP_DIRECT | GO:0051301∼cell division | 23 | 0.081057269 | 7.34E-12 |
| GOTERM_BP_DIRECT | GO:0030574∼collagen catabolic process | 10 | 0.035242291 | 1.47E-08 |
| GOTERM_BP_DIRECT | GO:0007062∼sister chromatid cohesion | 11 | 0.03876652 | 8.61E-08 |
| GOTERM_BP_DIRECT | GO:0008283∼cell proliferation | 17 | 0.059911894 | 9.22E-07 |
| GOTERM_CC_DIRECT | GO:0030496∼midbody | 12 | 0.042290749 | 3.90E-08 |
| GOTERM_CC_DIRECT | GO:0000777∼condensed chromosome kinetochore | 10 | 0.035242291 | 1.31E-07 |
| GOTERM_CC_DIRECT | GO:0005819∼spindle | 10 | 0.035242291 | 2.20E-06 |
| GOTERM_CC_DIRECT | GO:0000922∼spindle pole | 9 | 0.031718062 | 9.04E-06 |
| GOTERM_CC_DIRECT | GO:0000776∼kinetochore | 8 | 0.028193833 | 1.14E-05 |
| GOTERM_MF_DIRECT | GO:0004222∼metalloendopeptidase activity | 12 | 0.042290749 | 1.37E-08 |
| GOTERM_MF_DIRECT | GO:0004252∼serine-type endopeptidase activity | 15 | 0.052863436 | 2.15E-07 |
| GOTERM_MF_DIRECT | GO:0019901∼protein kinase binding | 14 | 0.049339207 | 8.48E-05 |
| GOTERM_MF_DIRECT | GO:0003777∼microtubule motor activity | 7 | 0.024669604 | 1.32E-04 |
| GOTERM_MF_DIRECT | GO:0042802∼identical protein binding | 19 | 0.066960352 | 3.92E-04 |
| dDEGs | ||||
| GOTERM_BP_DIRECT | GO:0007155∼cell adhesion | 38 | 0.059311981 | 9.75E-12 |
| GOTERM_BP_DIRECT | GO:0001525∼angiogenesis | 23 | 0.035899357 | 4.70E-09 |
| GOTERM_BP_DIRECT | GO:0007166∼cell surface receptor signaling pathway | 25 | 0.03902104 | 9.87E-09 |
| GOTERM_BP_DIRECT | GO:0001570∼vasculogenesis | 10 | 0.015608416 | 3.37E-06 |
| GOTERM_BP_DIRECT | GO:0045766∼positive regulation of angiogenesis | 13 | 0.020290941 | 8.80E-06 |
| GOTERM_CC_DIRECT | GO:0005578∼proteinaceous extracellular matrix | 30 | 0.046825248 | 1.58E-12 |
| GOTERM_CC_DIRECT | GO:0005886∼plasma membrane | 146 | 0.227882874 | 3.56E-10 |
| GOTERM_CC_DIRECT | GO:0005887∼integral component of plasma membrane | 68 | 0.106137229 | 1.70E-09 |
| GOTERM_CC_DIRECT | GO:0016021∼integral component of membrane | 161 | 0.251295499 | 3.09E-07 |
| GOTERM_CC_DIRECT | GO:0045121∼membrane raft | 19 | 0.029655991 | 7.41E-07 |
| GOTERM_MF_DIRECT | GO:0008201∼heparin binding | 17 | 0.026534307 | 2.62E-07 |
| GOTERM_MF_DIRECT | GO:0005509∼calcium ion binding | 38 | 0.059311981 | 4.32E-07 |
| GOTERM_MF_DIRECT | GO:0030246∼carbohydrate binding | 16 | 0.024973466 | 1.72E-05 |
| GOTERM_MF_DIRECT | GO:0005178∼integrin binding | 11 | 0.017169258 | 7.15E-05 |
| GOTERM_MF_DIRECT | GO:0003779∼actin binding | 18 | 0.028095149 | 8.51E-05 |
Abbreviations: dDEGS: downregulated differentially expressed gene; GO: Gene Ontology; NSCLC: non-small cell lung cancer; uDEGs: upregulated differentially expressed genes.