Table 3.
Regression Coefficients Testing the Interaction between Age at FMP and Time Segments From the Mixed Effect Model Regression Analyses
| Age at FMP by menopause status | Total cholesterol | LDL‐cholesterol | ApoB | Age at FMP by menopause status | Log triglycerides | Apo A1 | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| β(SE) | P Value | β(SE) | P Value | β(SE) | P Value | β(SE) | P Value | β(SE) | P Value | ||
| Model 0 | |||||||||||
| First observation to 3 y before FMP | −0.062 (0.063) | 0.33 | −0.027 (0.058) | 0.65 | 0.103 (0.053) | 0.051 | First observation to FMP | −0.001 (0.001) | 0.032 | −0.184 (0.032) | <.0001 |
| 3 y before to 1 y after FMP | 0.121 (0.086) | 0.156 | 0.080 (0.072) | 0.27 | 0.229 (0.069) | <.001 | |||||
| 1–3 y post‐FMP | −0.603 (0.162) | <.001 | −0.497 (0.139) | <.001 | −0.223 (0.136) | 0.010 | FMP to 3 y post‐FMP | −0.005 (0.001) | <.0001 | −0.446 (0.084) | <.0001 |
| >3 y post‐FMP | −0.046 (0.041) | 0.26 | −0.044 (0.033) | 0.184 | −0.102 (0.032) | 0.001 | >3 y post‐FMP | 0.0005 (0.0004) | 0.26 | 0.060 (0.028) | 0.035 |
| Model 1 | |||||||||||
| First observation to 3 y before FMP | −0.051 (0.064) | 0.43 | −0.019 (0.058) | 0.75 | 0.110 (0.053) | 0.037 | First observation to FMP | −0.001 (0.001) | 0.042 | −0.187 (0.032) | <.0001 |
| 3 y before to 1 y after FMP | 0.118 (0.086) | 0.168 | 0.075 (0.073) | 0.30 | 0.228 (0.069) | 0.001 | |||||
| 1–3 y post‐FMP | −0.611 (0.163) | <.001 | −0.506 (0.139) | <.001 | −0.241 (0.136) | 0.077 | FMP to 3 y post‐FMP | −0.006 (0.001) | <.0001 | −0.447 (0.085) | <.0001 |
| >3 y post‐FMP | −0.043 (0.041) | 0.29 | −0.040 (0.033) | 0.231 | −0.098 (0.032) | 0.002 | >3 y post‐FMP | 0.0005 (0.0004) | 0.25 | 0.058 (0.029) | 0.042 |
| Model 2 | |||||||||||
| First observation to 3 y before FMP | −0.032 (0.056) | 0.57 | −0.010 (0.051) | 0.85 | 0.129 (0.046) | 0.005 | First observation to FMP | −0.001 (0.001) | 0.061 | −0.186 (0.032) | <.0001 |
| 3 y before to 1 y after FMP | 0.158 (0.081) | 0.052 | 0.105 (0.069) | 0.126 | 0.250 (0.067) | <.001 | |||||
| 1–3 y post‐FMP | −0.525 (0.155) | <.001 | −0.384 (0.131) | 0.003 | −0.009 (0.137) | 0.95 | FMP to 3 y post‐FMP | −0.005 (0.001) | <.0001 | −0.438 (0.097) | <.0001 |
| >3 y post‐FMP | −0.071 (0.050) | 0.154 | −0.061 (0.040) | 0.131 | −0.059 (0.053) | 0.27 | >3 y post‐FMP | 0.001 (0.001) | 0.153 | −0.022 (0.054) | 0.68 |
Model 0: Adjusted for age at FMP and woman‐specific slope within time segments.
Model 1: Model 0 plus site, race, education, age at baseline.
Model 2: Model 1 plus ever smoking at baseline and time‐varying lipid‐lowering medication, cardiovascular events (stroke, heart attack, and angina), current smoker, body mass index, and hormone use.
Bold text indicates p values that are less than .05.
CVD indicates cardiovascular disease; FMP, final menstrual period; and LDL, low‐density lipoprotein.