Table 2.
Event Rate of the Outcomes by Tertiles of Systolic Standard Deviation and Cox Proportional Hazards Models Fit to the Outcomes
| Outcome | Tertile of systolic standard deviation (range in mm Hg) | Event rate, n, % | Unadjusted hazard ratio (95% CI) | P value | Adjusted hazard ratio* (95% CI) | P value |
|---|---|---|---|---|---|---|
| Probable dementia | Lowest (0.5–8.5) | 67/2796, 2.4% | Ref | … | Ref | … |
| Middle (8.5–12.3) | 99/2791, 3.6% | 1.51 (1.11–2.06) | 0.009 | 1.39 (1.02–1.91) | 0.037 | |
| Highest (12.3–41.1) | 150/2792, 5.4% | 2.36 (1.77–3.15) | <0.001 | 1.69 (1.25–2.28) | 0.001 | |
| Mild cognitive Impairment | Lowest (0.5–8.5) | 169/2796, 6.0% | Ref | … | Ref | … |
| Middle (8.5–12.3) | 195/2791, 7.0% | 1.18 (0.96–1.45) | 0.119 | 1.13 (0.92–1.40) | 0.237 | |
| Highest (12.3–41.1) | 264/2792, 9.5% | 1.64 (1.36–2.00) | <0.001 | 1.40 (1.14–1.71) | 0.002 | |
| Composite of probable dementia and mild cognitive impairment | Lowest (0.5–8.5) | 218/2796, 7.8% | Ref | … | Ref | … |
| Middle (8.5–12.3) | 264/2791, 9.5% | 1.24 (1.04–1.48) | 0.020 | 1.17 (0.97–1.40) | 0.094 | |
| Highest (12.3–41.1) | 370/2792, 13.3% | 1.94 (1.51–2.11) | <0.001 | 1.43 (1.20–1.71) | <0.001 |
*
Adjusted for patient age, sex, race/ethnicity, history of cerebrovascular disease, hypertension, education, level of physical activity, smoking status, percentage of study visits during the exposure with hypotension (SBP <90 or DBP <50 mm Hg), mean SBP during the exposure, and randomization arm. DBP indicates diastolic blood pressure; Ref, reference; and SBP, systolic blood pressure.