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. 2021 Nov 23;11:761960. doi: 10.3389/fonc.2021.761960

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Copyright © 2021 Guo, He, Ni, Ma, Cheng, Wang, Chen and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enriched expression of extracellular matrix-related proteins in the platinum-sensitive tumors. (A) Gene set enrichment analysis (GSEA) of a gene set for extracellular matrix-related proteins in the proteomic data. NES, normalized enrichment score; FDR, false discovery rate; PSR, platinum-sensitive recurrent high-grade serous ovarian cancer (HGSOC). PRR, platinum-resistant recurrent HGSOC. (B) Overlapping proteins of interest between the extracellular matrix gene cluster (matrisome) of 239 proteins and the upregulated proteins (platinum-sensitive tumors vs. platinum-resistant tumors). (C) Heatmap of Z-score normalized expression abundance values of the 42 overlapping proteins of interest hierarchically clustered with Euclidean distance matrix and complete linkage. Red, high abundance; and blue, low abundance.