Fig. 6.
The vitamin A byproduct, A2E, delivered intravitreally alters the inflammatory status of the retina. Cytokines in A2E-treated eyes (n=4 eyes) relative to control eyes (n=4 eyes) quantified by ELISA in homogenized retina. CNTF, ciliary neurotrophic factor; ICAM-1, intercellular adhesion molecule 1; IL-10, interleukin 10; MCP-1, monocyte chemotactic protein; PDGF-AA, platelet-derived growth factor alpha polypeptide; Cxcl7, Chemokine (C-X-C motif) ligand; TIMP-1, tissue inhibitor of metalloproteinases 1. Averages and standard deviations are shown. Numbers above bars are P-values comparing controls and treated. * P-value <0.05 as determined by a t-test.