Table 3.
Comparison of patients with skull base chordomas receiving GTR or STR.
| Postoperative Radiation | GTR | STR | P -value |
|---|---|---|---|
| Total number of patients | 187 | 378 | |
| Age (years) | 0.362 | ||
| <18 | 17 (9.1%) | 41 (10.9%) | |
| 18–39 | 51 (27.3%) | 109 (28.8%) | |
| 40–59 | 70 (37.4%) | 147 (38.9%) | |
| 60–79 | 42 (22.5%) | 76 (20.1%) | |
| 80+ | 7 (3.7%) | 5 (1.3%) | |
| Year of Diagnosis | 0.037 | ||
| 1973–1999 | 47 (28.1%) | 61 (16.1%) | |
| 2000–2009 | 72 (38.5%) | 159 (42.1%) | |
| 2010–2016 | 68 (36.4%) | 158 (41.8%) | |
| Gender | 0.915 | ||
| Male | 103 (55.1%) | 210 (55.6%) | |
| Female | 84 (44.9%) | 168 (44.4%) | |
| Race | 0.020 | ||
| White | 151 (80.7%) | 300 (79.3%) | |
| Black | 16 (8.6%) | 15 (4%) | |
| Others | 20 (10.7%) | 63 (16.7%) | |
| Marital Status | 0.833 | ||
| Unmarried | 56 (30%) | 117 (30.9%) | |
| Married | 125 (66.8%) | 252 (66.7%) | |
| Unknown | 6 (3.2%) | 9 (2.4%) | |
| Registry | 0.578 | ||
| Small | 43 (23%) | 95 (25.1%) | |
| Large | 144 (77%) | 283 (74.9%) | |
| Histological Subtype | 0.780 | ||
| Chordoma | 167 (89.3%) | 337 (89.1%) | |
| Chondroid chordoma | 20 (10.7%) | 40 (10.6%) | |
| Dedifferentiated chordoma | 0 (0%) | 1 (0.3%) | |
| Primary Site | 0.180 | ||
| Bones of skull and face | 126 (67.4%) | 287 (75.9%) | |
| Brain | 29 (15.5%) | 42 (11.1%) | |
| Pituitary gland | 14 (7.5%) | 19 (5%) | |
| Others | 18 (9.6%) | 30 (8%) | |
| Disease Stage | 0.052 | ||
| Localized | 74 (39.6%) | 182 (48.1%) | |
| Regional | 73 (39%) | 145 (38.4%) | |
| Distant | 24 (12.8%) | 26 (6.9%) | |
| Unknown | 16 (8.6%) | 25 (6.6%) | |
| Radiotherapy | 0.721 | ||
| No | 95 (50.8%) | 186 (49.2%) | |
| Yes | 92 (49.2%) | 192 (50.8%) | |
| Chemotherapy | 0.986 | ||
| No | 183 (97.9%) | 370 (97.9%) | |
| Yes | 4 (2.1%) | 8 (2.1%) | |
| Tumor Size (cm) | 0.327 | ||
| 0–2 | 19 (10.1%) | 108 (28.6%) | |
| 2–4 | 58 (31.0%) | 39 (10.3%) | |
| 4–6 | 31 (16.5%) | 135 (35.7%) | |
| >6 | 19 (10.1%) | 73 (19.3%) | |
| Unknown | 60 (32.0%) | 23 (6.1%) | |
| Overall Survival (%) | 0.104 | ||
| 5-Year Overall Survival | 74.1 | 81.2 | |
| 10-Year Overall Survival | 56.6 | 67.0 | |
| Tumor-specific Survival (%) | 0.316 | ||
| 5-Year Tumor-specific Survival | 81.7 | 84.3 | |
| 10-Year Tumor-specific Survival | 65.6 | 74.5 |
GTR, gross total resection; STR, subtotal resection.