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. 2021 Nov 23;12:788321. doi: 10.3389/fendo.2021.788321

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Copyright © 2021 Guo, Sheng, Wu, Chen and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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COVID-19 can cause erectile dysfunction. The potential mechanism of how COVID-19 infection is related to erectile dysfunction through impairing endothelial cell and smooth muscle cell (top panel); Ang1-7 is a potential novel drug target to treat erectile dysfunction in COVID-19 patients (bottom panel). ACE2, angiotensin-converting enzyme 2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; ED, erectile dysfunction; ROS, reactive oxygen species; AMPK, AMP-activated protein kinase; Ang1-7, angiotensin 1-7; Ang II, angiotensin 2; PDE, phosphodiesterase; 5’GMP, Guanosine-5’-monophosphate; cGMP, cyclic guanosine monophosphate; PKG, Cyclic GMP–dependent protein kinase; NOS, nitric oxide synthase. This scheme was created using BioRender, accessed on Sept. 29, 2021.