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. 2021 Nov 23;12:785463. doi: 10.3389/fimmu.2021.785463

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Copyright © 2021 Wang, Yi, Liu, Tan, Jin, Li, Zhou, Wang and Kang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HOTAIR regulated protein level associated with multiple biological progress, when applied to SILAC labeling-based proteome of U87 cells. (A) The scatter plot shows the number of differential proteins detected by proteome sequencing, with a difference ratio greater than 1.5. (B) STRING protein network shows that 434 proteins had high correlation. (C–F) Enrichment and clustering analysis of the quantifiable proteomics data set including HOTAIR associated biological processes clustering (C), KEGG pathway analysis (D), protein complex enrichment (E) and protein domains enrichment (F).