TABLE 1.
Tn7-like transposons mobilize diverse immune systems
| Immune mechanism | System | Component(s)a | No. of Tnsb | Phylum(a)c |
|---|---|---|---|---|
| Innate | Restriction-modification | Restriction endonucleases (COG0610, COG4096, COG3440, COG1002, COG3421, COG1715, COG3587, COG4636, COG4804, COG1403, COG3183, COG4127, COG4748) methylases (COG0286), specificity subunits (COG0732, COG4268, COG1401) | 947 | Pro, Act, Fir, Cy, Chl, Spi, Bac |
| Gabija | OLD nuclease (COG3593) | 338 | Pro, Fir, Act, Bac | |
| Sirtuin | Sirtuin2 (cl00195) | 242 | Pro, Act, Fir, Cy | |
| CBASS | Nucleotidyltransferase (cd05400) | 216 | Pro, Act, Fir | |
| Thoeris | ThsB (pfam08937) | 61 | Pro, Act, Fir | |
| Retron | RT (cd01646) | 50 | Pro, Act, Fir | |
| Hachiman | Hama (pfam08878) | 43 | Pro, Fir, Spi | |
| BREX | BrxC (NF033441) | 40 | Pro, Act, Fir, Cy, Nit, DT | |
| Wadjet | JetD (COG4924) | 34 | Pro, Act | |
| Kiwa | KwaB (pfam16162) | 23 | Pro, Act | |
| Nucleotide depletion | dGTPase (PRK05318), dCTPase (cd01286) | 21 | Pro, Fir | |
| PIWI | PIWI REase (pfam18154) | 19 | Pro, Act, Fir | |
| DND | DndE (pfam08870), DndB (pfam14072) | 14 | Pro, Bac, Fir, Cy | |
| Zorya | ZorA (pfam01618) | 3 | Pro | |
| Viperin | Viperin (TIGR04278) | 1 | Pro | |
| Toxin-antitoxin | ImmA | ImmA (COG2856, pfam06114) | 295 | Pro, Act, Bac, Fir, Cy |
| PIN | PIN (cl28905) | 251 | Pro, Act, Fir, Cy | |
| ParE | ParE (cl21503) | 120 | Pro, Act, Cy, DT | |
| RES | Res (cl02411) | 95 | Pro, Act, Fir | |
| RelA-SpoT | RelA (cd05403, COG1669, smart00954, cd05399, pfam14907, COG2357, pfam04607, pfam01909, cd07749) | 70 | Pro, Act, Bac, Fir, Cy | |
| HipA | HipA (cl28916) | 51 | Pro, Act, Cy | |
| AbiC | AbiC (pfam14355) | 48 | Pro, Fir | |
| HEPN | HEPN (cl00824) | 37 | Pro, Fir, Cy | |
| AbiF | AbiF (pfam07751, COG4823) | 23 | Pro, Spi | |
| AbiE | AbiEii (pfam08843, COG4849) | 19 | Pro, Act | |
| Fic/Doc | Doc (COG3654, TIGR02613) | 7 | Pro, Cy | |
| Barnase | BrnT (pfam04365, COG2929) | 5 | Pro, Cy | |
| Adaptive | Minimal I-F | Cas6_I-F, Csy3_I-F, Csy2_I-F | 304 | Pro |
| Minimal V-K | Cas12k | 78 | Cy | |
| Minimal I-B | Multiple | 9 | Cy | |
| Type III | Cas10 | 2 | Pro | |
| Type I-B | Multiple | 1 | Cy | |
a
Accession numbers in parentheses can be located at the NCBI Conserved Domain Database (CDD) (https://www.ncbi.nlm.nih.gov/cdd).
b
The number of transposons mobilizing each immune system is tabulated based on the listed components.
c
Pro, Proteobacteria; Act, Actinobacteria; Fir, Firmicutes; Cy, Cyanobacteria; Chl, Chloroflexi; Spi, Spirochaetes; Bac, Bacteroides; DT, Deinococcus-Thermus; Nit, Nitrosomonas.