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. 2021 Nov 23;23(1):68. doi: 10.3892/etm.2021.10991

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Copyright: © Tang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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SchB attenuates THP-induced oxidative stress in primary cardiomyocytes. THP reduced H9C2 (A) cardiomyocyte viability and (B) increased reactive oxygen species. Scale bar, 200 µm. (C) Similarly, the expression levels of SOD2, pro-caspase-3 and Bcl-2/Bax decreased, while the expression levels of NOX2 and cleaved-caspase-3 increased. However, after treatment with SchB, the aforementioned changes were significantly improved. (D) Semi-quantitative analysis of western blotting results. All values are presented as the mean ± SD. ^*P<0.05 vs. CON; ^#P<0.05 vs. THP. SOD, superoxide dismutase; NOX, NADPH oxidase; CON, control; SchB, schisandrin B; THP, pirarubicin.