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. 2021 Dec 6;79(1):1–9. doi: 10.1001/jamaneurol.2021.4346

Table 3. Secular Changes in Poor Outcomes at Discharge.

Outcome Odds ratio (95% CI)a
Crude Model 1b Model 2c Model 3d
Unfavorable outcome in women
Ischemic stroke 0.989 (0.984-0.994) 0.967 (0.962-0.972) 0.974 (0.967-0.981) 0.981 (0.973-0.988)
Intracerebral hemorrhage 0.996 (0.988-1.003) 0.984 (0.976-0.992) 0.987 (0.974-0.999) NA
Subarachnoid hemorrhage 0.986 (0.975-0.996) 0.974 (0.963-0.985) 0.973 (0.959-0.987) NA
Unfavorable outcome in men
Ischemic stroke 0.982 (0.977-0.987) 0.967 (0.962-0.972) 0.978 (0.971-0.985) 0.984 (0.977-0.991)
Intracerebral hemorrhage 0.999 (0.993-1.007) 0.991 (0.985-0.998) 1.001 (0.990-1.013) NA
Subarachnoid hemorrhage 0.989 (0.974-1.004) 0.981(0.966-0.997) 0.976 (0.956-0.995) NA
In-hospital death in women
Ischemic stroke 0.975 (0.967-0.983) 0.959 (0.951-0.967) 0.969 (0.959-0.979) 0.967 (0.957-0.978)
Intracerebral hemorrhage 0.984 (0.974-0.994) 0.976 (0.965-0.986) 0.978 (0.963-0.994) NA
Subarachnoid hemorrhage 0.970 (0.958-0.982) 0.960 (0.948-0.972) 0.951 (0.937-0.965) NA
In-hospital death in men
Ischemic stroke 0.964 (0.956-0.972) 0.950 (0.942-0.958) 0.966 (0.956-0.976) 0.967 (0.956-0.977)
Intracerebral hemorrhage 0.992 (0.983-1.001) 0.985 (0.977-0.994) 0.998 (0.985-1.012) NA
Subarachnoid hemorrhage 0.979 (0.962-0.996) 0.972 (0.955-0.990) 0.965 (0.945-0.986) NA

Abbreviations: NA, not applicable; NIHSS, National Institutes of Health Stroke Scale; WFNS, World Federation of Neurological Surgeons.

a

Odds ratio (95% CI) per 1 year.

b

Model 1 is adjusted by age.

c

Model 2 is adjusted by age, NIHSS score (WFNS grade for subarachnoid hemorrhage), and history of stroke.

d

Model 3 is adjusted by age, NIHSS score (WFNS grade for subarachnoid hemorrhage), history of stroke, and reperfusion therapy.