Figure 2.

Chronic renal injury in cardiorenal HFpEF and alleviated renal injury after treatment with Telmisartan. The mean ± SD of serum creatinine (a), blood urea nitrogen (b), and 24 h urine protein excretion (c) from Baseline to week 16. (d) Histopathological staining with anti-CD68 and calculated percentages of macrophages in renal sections. (e) Masson staining and calculated percentages of fibrosis in renal sections. Scale bar in (e), 100 μm. *P < 0.05, **P < 0.01, ***P < 0.001 for SNX+Veh vs. Sham; #P < 0.05, ##P < 0.01, ###P < 0.001 for SNX+Veh vs. SNX+Tel. Masson indicates Masson trichrome. (A color version of this figure is available in the online journal.)