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A diagram of the delivery strategy is shown. Pre-miR-122-miR-21-sponge is delivered into a cell by the GE11-MS2 VLP. It is further processed into miR-21-sponge and mature miR-122. The sponge is supposed to competitively combine with onco-microRNA miR-21, and tumor-suppressive microRNA miR-122 is supposed to increase. (A color version of this figure is available in the online journal.)
