TABLE 4.
Days to peak/nadir of the relevant parameters after CAR‐T cells infusion
| Parameters | Median (Range) |
|---|---|
| CRS peak | 8 (1 – 15) |
| Endothelial cell activation | |
| VWF peak | 5 (1 – 12) |
| Ang−1 peak | 5 (1 – 19) |
| Ang−2 peak | 6 (1 – 21) |
| sE‐selectin peak | 4.5 (1 – 12) |
| sVCAM−1 peak | 6 (3 – 14) |
| sICAM−1 peak | 4 (2 – 9) |
| Liver | |
| ALT peak | 9 (1 – 28) |
| AST peak | 9 (1 – 28) |
| Kidney | |
| BUN peak | 11 (1 – 28) |
| Cr peak | 10 (3 – 29) |
| Haematopoiesis | |
| SCF nadir | 7 (2 – 19) |
| SDF−1 nadir | 7 (1 – 19) |
| WBC nadir | 6.5 (1 – 20) |
| RBC nadir | 10.5 (1 – 27) |
| Hb nadir | 10 (1 – 27) |
| PLT nadir | 11.5 (2 – 28) |
Abbreviations: CRS = Cytokine release syndrome; VWF = von Willebrand factor; Ang‐1 = Angiopoietin‐1; Ang‐2 = Angiopoietin‐2; sICAM‐1 = soluble intercellular adhesion molecule‐1; sVCAM‐1 = soluble vascular cell adhesion molecule‐1; ALT = alanine aminotransferase; AST = aspartate aminotransferase; BUN = Blood urea nitrogen; Cr = Creatinine; SCF = stem cell factor; SDF‐1 = stromal cell–derived factor‐1; WBC = white blood cell; RBC = red blood cell; Hb = haemoglobin; PLT = platelet.