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. 2021 Nov 23;15:729482. doi: 10.3389/fnana.2021.729482

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Copyright © 2021 Yu, Cheng, Chen, Huang, He, Hu, Lin, Zou, Huang, Chen, Wan, Peng and Zou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The MRI signal intensity changes in different neck positions of CSM rats. (A,E) Representative images showing neutral position of a rat in the sham group. There was no material compressing the spinal cord. (B,F) Representative images showing neutral position of a CSM rat model. The compression material is localized on the posterior side at the C5/6 level of the cord. There existed a significantly higher T2WI contrast medium intensity at the injured site upon neutral position of a CSM rat compared with a sham model. (C,G) Representative images showing extension position of a CSM rat model. (D,H) Representative images showing flexion position of a CSM rat model. We found a significant hyperintense “pencil-like” lesion pattern on sagittal T2WIs and the so-called “snake eyes” with hyperintense signal conversion on axial T2WIs of CSM rats upon flexion. (I,J) Upon flexion, the T2WI signals of the cord at both sagittal and transverse sections were significantly more intense than that upon neutral or extension positions in CSM rats. (K,M) Histograms show the sagittal diameters of the spinal canal and spinal cord in the CSM group were significantly smaller than that in the sham group at all neck positions. At dynamic neck positions, the sagittal diameter of the cervical cord was the smallest upon flexion in CSM models, while remained unchanged in the sham group. (L,N) The transverse diameters of the canal and cord were similar between the CSM and sham groups and did not change at dynamic neck positions. **, *** indicated statistical significance (p < 0.01, 0.001, respectively) in the difference between the Sham and CSM group using t-test. # indicated statistical significance (p < 0.05) in the difference between different neck positions using one-way ANOVA and post hoc test.