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. Author manuscript; available in PMC: 2022 Aug 6.
Published in final edited form as: J Proteome Res. 2021 Jul 8;20(8):4089–4100. doi: 10.1021/acs.jproteome.1c00410

Table 3.

Comparison on the performance of TMH and topology prediction for bitopic transmembrane proteins (5 proteins in total).

Method Correct #TMH Correct topology Q3 SOV
Jufo9D 4 / 5 NA NA NA
MASSP 5 / 5 3 / 5 0.551 0.531
MEMSAT3 4 / 5 4 / 5 0.831 0.819
OCTOPUS 4 / 5 4 / 5 0.865 0.869
TMHMM2 4 / 5 3 / 5 0.629 0.630
TMP-SS 5 / 5 NA NA NA
TOPCONS2 3 / 5 4 / 5 0.589 0.584

NA: not available, Jufo9D and TMP-SS do not predict residue-level three-state topology. A predicted TMH is considered correct if it overlaps with the true TMH for at least 10 residues.