Table 3.

Propensity-adjusted multivariable Cox regression analysis of overall survival for locally advanced breast cancer.

Variable	HR (95% CI)	P value
Age distribution (years)
35-50	1 (Ref.)
<35	1.09 (0.54-2.21)	0.814
50-70	1.33 (0.83-2.14)	0.233
≥70	3.83 (1.81- 8.11)	<0.001 a
Race
White	1 (Ref.)
Asia/other	1.31 (0.45-3.81)	0.625
Black	1.59 (1.072-2.37)	0.021 a
Insurance
Not insured	1 (Ref.)
Medicaid	1.27 (0.48-3.35)	0.63
Medicare	0.67 (0.26-1.74)	0.406
Private Insurance/Managed Care	1.09 (0.44-2.67)	0.858
Income	1 (Ref.)
Low	1.35 (0.80-2.27)	0.259
High	1.09 (0.64-1.88)	0.741
High-middle	1.70 (0.99-2.90)	0.054
Low-middle
Home location
Rural/urban	1 (Ref.)
Metro	1.13 (0.59-2.19)	0.71
Charlson Comorbidity Index
C0	1 (Ref.)
C1	1.12 (0.62-2.02)	0.706
C2-3	1.48 (0.74-2.97)	0.266
Grade
G1-2	1 (Ref.)
G3-4	1.07 (0.72-1.60)	0.736
Tumor stage
T0-1	1 (Ref.)
T2	1.76 (0.96-3.25)	0.07
T3	2.09 (1.09-4.02)	0.027 a
T4	3.45 (1.82-6.54)	<0.001 a
Nodal stage
N0	1 (Ref.)
N1	3.37 (1.48-7.68)	0.004 a
N2	10.01 (4.59-21.83)	<0.001 a
N3	10.26 (4.62-22.78)	<0.001 a
Stage
S0-2	1 (Ref.)
S3-4	0.71 (0.30-1.68)	0.436
Chemotherapy
No	1 (Ref.)
Yes	1.06 (0.58-1.94)	0.855
Hormone therapy
No	1 (Ref.)
Yes	1.60 (0.71-3.58)	0.254
Immunotherapy
No	1 (Ref.)
Yes	1.46 (0.52-4.13)	0.472
Subtype
Luminal	1 (Ref.)
Triple negative	9.02 (3.90-20.86)	<0.001 a
Her-2	4.17 (1.48-11.72)	0.007 a
Surgery
Simple mastectomy	1 (Ref.)
BCS/other	1.80 (0.89-3.62)	0.1
Radical mastectomy	1.71 (1.10-2.66)	0.017 a
Radiotherapy
Postoperative radiotherapy	1 (Ref.)
Preoperative radiotherapy	1.23 (0.88-1.72)	0.218

BCS, breast-conserving surgery; HR, hazard ratio.

^aThe statistical tests were two sided, the significance level was 0.05.