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. 2021 Nov 23;12:761418. doi: 10.3389/fgene.2021.761418

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Copyright © 2021 Kim, Robles-Lopez, Cao, Liu, Chothani, Bhavani, Rahman, Mukhopadhyay, Wlodarczyk and Finnell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The transcriptomic analysis of the midbrains of Gpr161 cKO fetuses at E13.5. (A) The Heat map from dissected midbrain tissues of Gpr161 ^f/f (floxed control), Gpr161 ^f/+ ;Wnt1-Cre/+ (Cre control) and Gpr161 ^f/f ;Wnt1-Cre/+ (cKO) fetuses at E13.5 (n = 3). Top 25 DEGs were displayed in Heat map (Top 6 downregulated genes in Green in cKO and top 19 upregulated genes in Red in cKO). (B) Top ten differentially regulated genes (DEGs) in Gpr161 cKO (C) Gene Ontology (GO) analysis of DEGs in Gpr161 cKO.