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. 2021 Nov 23;12:789914. doi: 10.3389/fimmu.2021.789914

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Copyright © 2021 Du, Wu, Gao, Jiang, Wang, Zhang and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Features of m6A modification in TCGA molecular subgroups and cancer somatic mutation. (A) The distribution differences of the tumor mutational burden between low and high m6A score in the TCGA-AML cohort. (B) The correlation between m6A score and TMB was not significant. (C) Survival assay for low (71 patients) and high (17 patients) TMB groups using KM curves (p = 0.042, log-rank test). (D) Survival analyses for patients classified by m6A score and TMB using KM curves. H, high; L, Low. (p < 0.001, log-rank test). (E, F) Waterfall plot of cancer somatic mutations constructed from patients with high m6A score (E) and low m6A score (F). Every column represents a single patient. The bar plot above presents TMB, the figure on the right denotes the mutational frequency of each gene. The bar plot on the right represents the level of each variation type.