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. 2021 Dec 6;14(Suppl 3):290. doi: 10.1186/s12920-021-01137-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Identification of correlated lncRNA-mRNA pairs and associated lncRNAs. A The distribution of the SCCs of lncRNA-mRNA pairs. B The distribution of the number of correlated mRNAs per lncRNA. The lncRNA-positively correlated mRNAs are defined as top 0.1% of mutual rank index (yellow) of lncRNA-mRNA pairs; the lncRNA-negatively correlated mRNAs are defined as bottom 0.1% of mutual rank index (blue) of lncRNA-mRNA pairs. C The PCC between each lncRNA was calculated considering the number of their correlated mRNAs. The distribution of PCC according to the lncRNA-positively correlated mRNAs (blue) and lncRNA-negatively correlated mRNAs (yellow) were plotted. N, measurement according to lncRNA-negatively correlated mRNAs; P, measurement according to lncRNA-positively correlated mRNAs; SCC, spearman’s rank correlation coefficient