Skip to main content
. 2021 Dec 7;19:499. doi: 10.1186/s12967-021-03165-x

Fig. 2.

Fig. 2

In vitro expansion of T cells and CAR-T cells require proper metabolism(directly or indirectly inhibit glycolysis) to maintain undifferentiated state, which can extend the duration in vivo and enhance anti-tumor activity; However, in vivo it is necessary to enhance metabolic (glycolysis or OXPHOS) activity to maintain high invasion potential and killing function