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Changes of the BL and its major components in ALS
| ALS | Changes | Models | References | |
|---|---|---|---|---|
| BL | Rodents | Thickening, duplication | SOD1G93A | [40] |
| Humans | Exposed to plasma proteins | - | [48] | |
| Collagen IV | Rodents | ↑ | SOD1G93A | [45] |
| Humans | ↑ | - | [48] | |
| ↓ | - | [45, 337, 338] | ||
| ↔ | - | [339] | ||
| Laminin | Rodents | ↓ | SOD1G93A | [41] |
| Humans | ↑ | - | [340, 341] | |
| ↔ | - | [339] | ||
| ↓ | - | [342] | ||
| Nidogen | Rodents | Unknown | ||
| Humans | ||||
| Agrin | Rodents | ↓ | SOD1G93A | [43, 343] |
| Humans | ↔ | - | [339] | |
| Perlecan | Rodents | Unknown | ||
| Humans | ||||
